High entropy alloys (HEAs) have garnered significant attention due to their distinctive properties, while their precise regulation remains at infancy stage. Herein, we report PtSnBiPdIn HEA nanoparticles with tensile-strain and nanoporous structures as high-performance electrocatalysts for oxidation of ethylene glycol to CO₂. The mass activity (MA) of the PtSnBiPdIn/C catalyst for alkaline ethylene glycol oxidation reaction (EGOR) are 29.76 A·mg_Pt+Pd⁻¹, which not only substantially surpasses those of commercial Pt/C and Pd/C catalysts but also ranks among the best reported EGOR catalysts. Moreover, this catalyst also greatly enhances in electrocatalytic performance for both methanol oxidation reaction (MOR) and ethanol oxidation reaction (EOR), showcasing its versatility across a wide range of alcohol oxidation reactions. In-situ Fourier transform infrared (FTIR) spectroscopy confirms the preferential selection of the non-CO reaction pathway. Density functional theory (DFT) calculation reveals that the PtSnBiPdIn HEA nanoparticles exhibit enhanced electron transfer, superior catalytic activity, and remarkable CO poisoning resistance.