Advanced glycation end products (AGEs) are a series of stable compounds generated by the nonenzymatic reaction of reducing sugars with proteins, lipids or nucleic acids. It has been found that the excessive accumulation of AGEs in the body can easily cause various chronic diseases such as diabetes, atherosclerosis, Alzheimer’s diseases and cardiovascular diseases. Finding methods to suppress the formation of AGEs is of great significance for ensuring human health. This article summarizes the types, structures, formation process, pathogenesis, and in vivo metabolic pathways of AGEs, with a focus on the methods and mechanisms for the inhibition of AGEs. This review will provide a theoretical basis for controlling the formation of AGEs.

This study investigated the effect of electron beam generated X-ray (EBGX) irradiation at different doses (0, 0.3, 0.6, 0.9 and 1.2 kGy) on the storage quality of harvested Agaricus bisporus at (15 ± 1) ℃. The results indicated that EBGX-treated mushroom had significant superiority in delaying mass loss, maintaining apparent color and textural properties, and promoting phenol accumulation compared with the non-treatment group. Different from the other irradiation doses, the 0.9 kGy treatment effectively delayed the rate of superoxide anion radical production, reduced the accumulation of reactive oxygen species (ROS), enhanced the activities of superoxide dismutase (SOD) and catalase (CAT), and inhibited microbial growth. It is suggested that EBGX treatment can obviously delay the quality deterioration of A. bisporus during storage. This study provides a theoretical basis for the application of EBGX treatment in the preservation of A. bisporus.