Advancing sustainable hydrogen production relies on the creation of effective electrocatalysts for the hydrogen evolution reaction (HER). Ruthenium (Ru) is a potential alternative to platinum due to its lower cost and high activity, yet its performance in alkaline HER remains limited by sluggish reaction kinetics. Herein, we propose a strategy to modulate electronic asymmetry within Ru clusters by anchoring Ru nanoclusters on N-doped graphene (Ru-NC), optimizing the charge distribution between high-valent Ruⁿ⁺ and metallic Ru⁰ sites. The Ru-NC catalyst, having a Ruⁿ⁺/Ru⁰ ratio of 57.1%, demonstrates superior HER activity with an overpotential of merely 29 mV at 10 mA·cm⁻² and a Tafel slope of 46 mV·dec⁻¹ in 1.0 M KOH, surpassing the performance of Pt/C catalyst. Experimental and structural analyses reveal that the asymmetric electronic configuration facilitates H₂O dissociation at Ruⁿ⁺ sites and efficient H adsorption/desorption at Ru⁰ sites, synergistically lowering energy barriers for HER intermediates. Furthermore, Ru-NC demonstrates remarkable stability, retaining its activity after 5000 cycles and operating continuously for 80 h at 100 mA·cm⁻² with minimal degradation. This work highlights the pivotal role of electronic asymmetry in enhancing HER kinetics and provides a rational design principle for high-performance Ru-based electrocatalysts.