Recently, the variable coefficient homogeneous differential equations (VCHDE) have been widely applied to real-world problems, such as wave propagation and material science. However the exploration and research on higher-order VCHDE is relatively lagging. Given this, this work focuses on the solutions of fourth-order and nth-order VCHDE with polynomial coefficients. By means of the sufficient conditions for the existence of solutions to differential equations, a connection is established between the rank of the variable coefficient matrix and the existence of polynomial particular solutions. The main results show that: (1) the necessary and sufficient conditions for the existence of polynomial particular solutions of fourth-order VCHDE are derived; (2) the necessary and sufficient conditions for the existence of only one polynomial particular solution, or the existence of two, three, or four linearly independent polynomial particular solutions of fourth-order VCHDE are proved; (3) the necessary and sufficient conditions for the existence of only one polynomial particular solution, or the existence of two, three, or four linearly independent polynomial particular solutions of nth-order VCHDE are proved. These results not only extend the class of solvable differential equations, but also provide a new way of thinking about the existence of solutions to VCHDE.