In light of Huangdi Neijing (The Yellow Emperor's Inner Classic), compiled in the name of Qibo, the founder of Chinese medicine, the theory of "relationship between meridians and zangfu" within meridian-collateral system has been systematically refined. Under the guidance of this theory, acupuncture-moxibustion therapy has made an indelible contribution to safeguarding health of the Chinese nation throughout its long historical development. Notably, during nearly the same historical period, Galenus, a representative figure in ancient Greek and Roman medicine, proposed a theory of surface-viscus connection known as "homoeomeria". Although stemming from distinct Eastern and Western cultural and philosophical frameworks, both theories collectively reveal a natural correlation between specific "regions" on the human body surface and their corresponding internal "target organs", and regard these "regional domains" as the key "therapeutic sites" for treating the corresponding diseases. This consensus that transcends cultural and geographical boundaries not only reflects the profound exploration of holistic view of life in ancient medicine, but also demonstrates the collective wisdom of humanity in elucidating patterns between the body and diseases. Furthermore, it provides invaluable historical origins and theoretical foundations for subsequent research in related fields.

The wisdom of Chinese medicine in maintaining health is “Yin Ping Yang Mi” (balance between yin and yang). Obviously, the maintenance of “homeostasis” contains dual factors of “excessiveness” and “falling short”. The life process must be protected by the stability-maintaining mechanism of the “bidirectional regulation” system. Therefore, the two-way regulation of the “homeostasis” maintaining involves the relatively independent potential energyof the “spear” and “shield”, and also depends on two sets of relatively independent regulatory systems to complete. Acupuncture is an excellent performer of the “bidirectional regulation effect” of living organisms, but can this effect becaused by a single acupoint stimulation? This issue, which was not a problem, has become a big problem inacupuncture-moxibustion discipline. The concept of “two-way regulation” of acupuncture is over-expanded, which isdifficult for the theory of Chinese medicine to take into account. It is only a broad expansion of the boundary oftheoretical extension arbitrarily. From the perspective of life science, the present paper expounds that the “bidirectionalregulation effect” of acupuncture is obtained from the activation of the “integration center” (not necessarily limited to thebrain) by the stimulated acupoints at different somatic parts of the body, and through two sets of relatively independentregulation systems, so as to maintain the life’s “homeostasis”.