Seawater electrolysis holds great promise for sustainable green hydrogen production, but it is challenged by chloride-induced corrosion. Herein, we demonstrate the hydrothermal preparation of Pb-doped NiFe layered double hydroxide on Ni foam (Pb-NiFe LDH/NF) for alkaline seawater oxidation electrocatalysis. Our Pb-NiFe LDH/NF requires a low overpotential of only 381 mV to attain a current density of 1000 mA·cm⁻², superior to its NiFe LDH/NF counterpart (423 mV). Additionally, it operates continuously for 1000 h with negligible performance degradation and minimal active chlorine production. In situ Raman spectroscopy analysis reveals that Pb incorporation facilitates catalyst surface reconstruction, thereby enhancing oxygen evolution reaction activity. Importantly, Pb selectively adsorbs free Cl⁻ to form stable Pb–Cl species under the influence of an applied electric field. This process creates a Cl⁻-free layer near the anode surface, thereby enhancing the catalyst’s chlorine corrosion resistance.