The treatment of multidrug-resistant bacteria is a difficult problem in clinical practice. These drug-resistant bacteria have reduced sensitivity to antibiotics, which contributes to the high incidence and mortality of bacterial infections worldwide. Photothermal therapy and chemodynamic therapy are advanced nanomaterial-based medical treatment methods and are widely used in tumor and antibacterial therapies due to their precision and rapidity. To overcome the limitations of conventional treatment for bacterial resistance, this study developed a near-infrared-II (NIR-II) responsive nanomaterial, a gold nanoframework coated with copper selenide (GNF@CS). This nanomaterial simultaneously triggers both chemodynamic therapy and photothermal therapy, while further promoting the chemodynamic process through in-situ heat generation. Ultimately, it shows significant antibacterial effects against both Staphylococcus aureus and Escherichia coli, providing a new non-antibiotic-dependent treatment strategy for clinically relevant bacterial infections.