This work explores the correlation between the characteristics of the cast structure (dendrite growth pattern, dendrite morphology and macro-texture) and strain hardening capacity during high temperature deformation of Mg-5Sn-0.3Li-0 and 3Zn multi-component alloys. The three dimensional (3D) morphology of the dendrite structure demonstrates the transition of the growth directions from <1123>,<1120> and <1122> to< 1123> and <1120> due to the addition of Zn. The simultaneous effects of growing tendency and the decrement of dendrite coarsening rate at the solidification interval lead to dendrite morphology transition from the globular-like to the hyper-branch structure. This morphology transition results in the variation of the solidification macro-texture, which has effectively influenced the dominant deformation mechanisms (slip/twin activity). The higher activity of the slip systems increases the tendency of the dendrite arms for bending along the deformation direction and fragmentation. Apart from this, the dendrite holding hyper-branch structure with an average thickness below 20 µm are more favorable for fragmentation. The dendrite fragmentation leads to considerable softening fractions, and as an effective strain compensation mechanism increases the workability of dendritic structure.