Graphs give a mathematical model of molecules, and thery are used extensively in chemical investigation. Strategically selections of graph invariants (formerly called "topological indices" or "molecular descriptors") are used in the mathematical modeling of the physio-chemical, pharmacologic, toxicological, and other aspects of chemical compounds. This paper describes a new technique to compute topological indices of two types of chemical networks. Our research examines the mathematical characteristics of molecular descriptors, particularly those that depend on graph degrees. We derive a compact mathematical analysis and neighborhood multiplicative topological indices for product of graphs ( $\mathcal{L}$) and tetrahedral diamond lattices ( $\mathrm{\Omega }$). In this paper, the fifth multiplicative Zagreb index, the general fifth multiplicative Zagreb index, the fifth multiplicative hyper-Zagreb index, the fifth multiplicative product connectivity index, the fifth multiplicative sum connectivity index, the fifth multiplicative geometric-arithmetic index, the fifth multiplicative harmonic index and the fifth multiplicative redefined Zagreb index are determined. The comparison study of these topological indices is also discussed.