For the rapid development of the cruise industry, the cruise disaster relief supply chain has attracted extensive attention, especially because COVID-19 cases on international cruise ships occurred. In this paper, we propose an idea of coordination layout for cruise ship emergency supplies, the problem optimized two objective functions of maximizing coverage satisfaction and minimizing the total cost, addressing the low efficiency of resource utilization at the same. By applying to cruise ship emergency supplies layout of Northeast Asia cruise port group system, using expert scoring method and AHP to evaluate cruise port security vulnerability. The NSGA-II algorithm is used to solve the multi-objective programming model. A numerical example shows that the optimization design model and method are valid and feasible, and the algorithm is efficient for solving the above collaborative location and allocation problem of sectional reserves, which can also offer a variety of decision-making options.