Transcription factors (TFs) play key roles in the regulatory network of leaf senescence. However, many nodes in this network remain unclear. To elucidate the mechanism of leaf senescence mediated by a rice TF, WRKY10, the expression of multiple senescence-related genes and physiological phenotypes were monitored in WRKY10- and VQ MOTIF-CONTAINING PROTEIN8 (VQ8)-overexpressing plants and the wrky10 and vq8 mutants. Our results showed that WRKY10 positively regulates abscisic acid (ABA)- and dark-induced senescence (DIS) by directly regulating the expression of multiple senescence-related genes. The VQ8 protein, a repressor of WRKY10, negatively regulates WRKY10-mediated DIS. The WRKY10-VQ8 module fine-tunes the progression of DIS. ABA, methyl jasmonate, and H₂O₂ accelerate WRKY10-mediated DIS, whereas ammonium nitrate and dithiothreitol delay WRKY10-mediated DIS. Further analysis revealed that WRKY10 and VQ8 interact with ABA RESPONSIVE ELEMENT BINDING FACTOR1 (ABF1) or ABF2. VQ8 represses the transcriptional activity of ABF1 and ABF2. Overexpression of ABF1 or ABF2 accelerates ABA- and dark-induced senescence and H₂O₂ accumulation in N. benthamiana leaves, and WRKY10 and VQ8 can inhibit either ABF1- or ABF2-induced cell necrosis. Taken together, WRKY10 integrates multiple senescence signals to establish an orderly progression of leaf senescence. The VQ8 protein acts as a brake on WRKY10-induced senescence and ABF1/2-induced cell death, preventing uncontrolled cell death.