Air pollutants significantly induce a series of environmental issues and pose serious risks to human health, prompting increasingly stringent regulations governing atmospheric environmental quality. Volatile organic compounds (VOCs) play a critical role in the synergistic prevention and control of composite pollutants such as ozone and particulate matter (PM_2.5). Consequently, advancing the elimination of VOCs has emerged as a vital area of research. Catalytic oxidation is widely recognized for its economic viability, low carbon footprint, and environmentally friendly attributes in the treatment of VOCs, indicating promising prospects for application development. In this perspective, we assert that two key aspects—adaptive active site and synergistic catalytic oxidation—are of paramount importance for the advancement and implementation of catalytic oxidation strategies aimed at mitigating VOCs emissions.