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Open Access Basic Research Issue
Using Network Pharmacology and Molecular Docking to Explore the Mechanism by Which Dracocephalum rupestre Hance Tea Intervenes in Hyperlipidemia
Food Science 2023, 44(9): 7-14
Published: 15 May 2023
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The purpose of this study was to comprehensively explain the key components and mechanism of action of tea made from the leaves of Dracocephalum rupestre Hance (DRH) for intervening in hyperlipidemia by using network pharmacology and molecular docking. Eight active components of DRH tea and 160 targets for intervention in hyperlipidemia were selected by using the Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP), and a ‘DRH tea-active ingredients-intersection targets-hyperlipidemia’ network was constructed. Gene ontology (GO) pathway analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that the tumor necrosis factor (TNF) signaling pathway, insulin resistance and the peroxisome proliferators-activated receptor (PPAR) signaling pathway were mainly involved in the intervention of DRH tea in hyperlipidemia. Molecular docking and visual analysis showed that the core components of DRH tea could be stably combined with the key targets. Therefore, it is speculated that DRH tea intervenes in hyperlipidemia through the synergistic effect of multi-components, multi-targets, and multi-pathways, which can provide a theoretical basis for the development and utilization of plant resources for herbal tea.

Open Access Review Issue
Research Progress on the Application of Ultrasonic in the Meat Field Based on Bibliometric Analysis
Meat Research 2024, 38(4): 62-69
Published: 30 April 2024
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Ultrasound, as a green processing technology, is garnering more and more attention. In order to further understand the application of ultrasound in the meat field, bibliometric analysis using CiteSpace and HistCite was performed on 3624 pieces of literature pertaining to “Ultrasound” or “Ultrasonic” and “Meat” retrieved from the Web of Science (WOS) Core Collection database from 2009 to 2023. Text mining was performed for the number of articles, authors, countries, institutions and journals, and data visualization and analysis through keyword clustering and burst term maps were conducted in order to summarize the evolution and trend of meat research. The results showed that ultrasonic has attracted growing interest among meat researchers, and the total number of published articles is on the rise, and the journals with large publication volume are mostly the top ones in the meat field, and the number of articles published by China is 1650, which ranks first in the world, accounting for 45.53% of the total number of articles. Additionally, the US, Spain, Iran and other countries have published a large number of research articles in this field. There has been close between authors and research institutions in different regions and between countries, and academic teams with China as the core have been formed. The research mainly focuses on the application of ultrasonic in research on the functional properties of food, the extraction of bioactive substances from food and the inactivation of microorganisms in food, and future trends include ultrasound-assisted extraction, myofibrillar proteins and bacteriostatic activity. The results of the study show that ultrasonic in meat research is still in its active development stage and has good research prospects.

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