With the continuous development of drug delivery technology, natural polyphenol self-assembled drug delivery systems (DDS) have become a research focus due to their unique advantages. Polyphenols can not only serve as drugs themselves but also as components of self-assembled drug delivery systems, broadening their application in the field of drug delivery. This article reviews the mechanisms of interactions between polyphenols and other molecules, and analyzes the process of constructing drug delivery systems with polyphenols. At the same time, it deeply explores the multiple functions of polyphenol self-assembled complexes in drug delivery, such as enhancing drug efficacy, achieving precise targeted delivery, and overcoming biological barriers, highlighting their great potential in enhancing drug efficacy and reducing side effects. In addition, several advanced characterization and preparation techniques are introduced and discussed, which will help to deeply understand and evaluate the structure and performance of polyphenol self-assembled delivery systems, promoting their further development. Finally, the challenges and future intelligent manufacturing strategies of polyphenol self-assembled complexes are summarized.

Oral liquid has the advantages of large drug loading, simple preparation and rapid effect. The substances of medicine and food homology (SMFH) are mostly developed into the form of oral liquid and prepared by high-temperature steam sterilization (HPSS). However, due to the complex composition of the solution, it is easy to be affected by HPSS and produce a series of unstable phenomena, which has become the key to hinder the development of the medicine and food homology oral liquid (MFHOL). Based on the characteristics of HPSS, this paper analyzed the chemical composition and physical phase interaction in the solution, discussed the mechanism and influencing factors of MFHOL instability induced by this method, as well as put forward feasible future solutions. Through the analysis and summary of the literature on oral liquid instability, it was found that HPSS can cause dramatic changes in the chemical composition of MFHOL, lead to changes of the physical phase, as well as produce a series of chain reactions, which seriously affect its stability. At the same time, this paper introduced the new sterilization technology that can be applied to the production of MFHOL in the future, put forward the personalized sterilization program and the establishment of intelligent continuous sterilization system according to the characteristics of SMFH. So as to provide the corresponding theoretical basis for the efficient and reasonable sterilization of MFHOL, in order to promote its further development.