High activity and durable structural catalysts are increasingly needed for carbon monoxide (CO) catalytic removal of industrial flue gas. A series of structural catalysts were prepared by coating polymetallic oxide catalyst on cordierite honeycomb supports. The results showed that silica sol and hot air drying could promote the powder catalyst to evenly and compactly spread on the surface of the support, and improve the anti-shedding performance and catalytic performance of the structural catalyst. The coating shedding rate of the optimized catalyst after 60 min of ultrasonic vibration was 0.97%. The catalytic efficiency of 99% CO can be achieved at 7500 h^–1 space speed, 1% CO, 8% water vapour content and 110 ℃, and remains stable within 72 h. The CO catalytic efficiency can be stabilized above 86% after 720 h in actual sintering flue gas condition.