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Open Access Review Article Issue
Visual-language foundation models and artificial intelligence agents in healthcare: Bridging from technological innovation to clinical impact
Computational Visual Media 2026, 12(5): 1225-1262
Published: 14 October 2026
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Recent advances in foundation models (FMs) have enabled artificial intelligence systems to acquire generalizable capabilities, with language and visual models demonstrating adaptability across diverse healthcare applications and multimodal vision-language FMs (VLFMs) supporting complex tasks such as report generation and question answering. Building on these developments, autonomous agents, particularly vision-language agents (VLAs), represent the next frontier, extending AI from perception and recognition to cognition, decision-making, and action. By integrating multimodal understanding with planning, interaction, and tool use, VLAs introduce autonomous intelligence capable of managing multi-step clinical workflows, adapting over time, and collaborating with clinicians. This survey provides a comprehensive perspective on VLAs in healthcare. We examine their current progress, analyze the major challenges hindering their integration, and highlight promising directions for future development. Unlike prior surveys that primarily focus on diverse FMs, our work prioritizes emerging VLFMs and incorporates agentic concepts, emphasizing their transformative potential beyond narrow research prototypes. Specifically, we (ⅰ) evaluate VLAs in terms of VLFM architectures and adaptation strategies and agentic design, (ⅱ) assess their potential impact across diverse clinical workflows, and (ⅲ) discuss pathways towards next-generation clinical decision support, considering technical and clinical challenges.

Open Access Review Issue
Caregiving in Asia: Priority areas for research, policy, and practice to support family caregivers
Health Care Science 2024, 3(6): 374-382
Published: 18 December 2024
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Population aging presents a growing societal challenge and imposes a heavy burden on the healthcare system in many Asian countries. Given the limited availability of formal long‐term care (LTC) facilities and personnel, family caregivers play a vital role in providing care for the increasing population of older adults. While awareness of the challenges faced by caregivers is rising, discussions often remain within academic circles, resulting in the lived experiences, well‐being, and needs of family caregivers being frequently overlooked. In this review, we identify four key priority areas to advance research, practice, and policy related to family caregivers in Asia: (1) Emphasizing family caregivers as sociocultural navigators in the healthcare system; (2) addressing the mental and physical health needs of family caregivers; (3) recognizing the diverse caregiving experiences across different cultural backgrounds, socioeconomic status, and countries of residence; and (4) strengthening policy support for family caregivers. Our review also identifies deficiencies in institutional LTC and underscores the importance of providing training and empowerment to caregivers. Policymakers, practitioners, and researchers interested in supporting family caregivers should prioritize these key areas to tackle the challenge of population aging in Asian countries. Cross‐country knowledge exchange and capacity development are crucial for better serving both the aging population and their caregivers.

Open Access Original Article Issue
Explainable machine learning model for pre‐frailty risk assessment in community‐dwelling older adults
Health Care Science 2024, 3(6): 426-437
Published: 10 December 2024
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Background

Frailty in older adults is linked to increased risks and lower quality of life. Pre‐frailty, a condition preceding frailty, is intervenable, but its determinants and assessment are challenging. This study aims to develop and validate an explainable machine learning model for pre‐frailty risk assessment among community‐dwelling older adults.

Methods

The study included 3141 adults aged 60 or above from the China Health and Retirement Longitudinal Study. Pre‐frailty was characterized by one or two criteria from the physical frailty phenotype scale. We extracted 80 distinct features across seven dimensions to evaluate pre‐frailty risk. A model was constructed using recursive feature elimination and a stacking‐CatBoost distillation module on 80% of the sample and validated on a separate 20% holdout data set.

Results

The study used data from 2508 community‐dwelling older adults (mean age, 67.24 years [range, 60–96]; 1215 [48.44%] females) to develop a pre‐frailty risk assessment model. We selected 57 predictive features and built a distilled CatBoost model, which achieved the highest discrimination (AUROC: 0.7560 [95% CI: 0.7169, 0.7928]) on the 20% holdout data set. The living city, BMI, and peak expiratory flow (PEF) were the three most significant contributors to pre‐frailty risk. Physical and environmental factors were the top 2 impactful feature dimensions.

Conclusions

An accurate and interpretable pre‐frailty risk assessment framework using state‐of‐the‐art machine learning techniques and explanation methods has been developed. Our framework incorporates a wide range of features and determinants, allowing for a comprehensive and nuanced understanding of pre‐frailty risk.

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