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Original Article Issue
A technology for fast recognition of fear emotions based on fNIRSNet
Military Medical Sciences 2025, 49(11): 823-828
Published: 25 November 2025
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Objective

To establish a technology for rapid recognition of fear emotions in order to facilitate the monitoring and interventions of fear emotions among personnel doing unusual jobs based on the fNIRSNet model.

Methods

Functional near infrared spectroscopy (fNIRS) was used to record the changes of cerebral blood oxygen activities in 50 subjects watching non-thrilling and thrilling videos, whose emotions were assessed based on Sel f-Assessment Manikin (SAM). Signals of blood oxygen in response to the two types of videos were labeled and preprocessed. Channels with significant differences were identified by calculating the Beta value. The features of data on fNIRS in the activated region of the brain where the channels were located were extracted. The fNIRSNet algorithm was used to establish a fear emotion recognition model, and the accuracy was evaluated using the 50-fold cross-validation method.

Results

The SAM showed that fear emotions were induced, and the brain region activated by fear emotions was located in the medial prefrontal cortex. The fNIRSNet algorithm could help classify fear emotions with high precision by analyzing the data on the 20 s short time series, with an accuracy of 82.36%.

Conclusion

This technology for emotion recognition based on the fNIRSNet model is capable of rapid and accurate assessment of fear emotions, which can be used for related monitoring and interventions.

Open Access Research Article Issue
Salidroside alleviates ferroptosis of retinal ganglion cells in db/db mice
Food Science and Human Wellness 2025, 14(6): 9250349
Published: 30 June 2025
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Salidroside (Sal), is one of the important food supplements from the traditional Chinese medicine Integripetal rhodiola herb, encapsulating significant anti-oxidative stress, anti-ferroptosis, and neuroprotective attributes. Notwithstanding these latent virtues, the ramifications of Sal on retinal ganglion cells (RGCs) impairment during the incipient stages of diabetic retinopathy (DR) remain equivocal. The purpose of this study was to investigate inhibitory effect of Sal on ferroptosis of RGCs in db/db mice. Within the research conducted, Sal was administered via gavage, and observations were made 8 weeks post-treatment. Retinal samples were collected for analysis. The results evidenced that Sal ameliorated blood glucose levels, attenuated RGCs destruction, and augmented visual functionality in db/db mice. Additionally, Sal exerted an anti-ferroptosis impact on the RGCs in the db/db mice. Successive discoveries have outlined the involvement of the HIF-1α/HO-1 signaling pathway in this protective mechanism. Ferroptosis of RGCs has a contributory effect on the development of DR, in part through the HIF-1α/HO-1 pathway. Intriguingly, Sal reversed the alterations in the HIF-1α/HO-1 pathway in db/db mice and displayed prospective advantageous effects on DR. Sal mitigated RGCs ferroptosis by reducing blood sugar and impeding the HIF-1α/HO-1 signaling pathway, thereby improving DR. Thus, Sal shows potential for use as a pharmaceutical and nutraceutical for DR.

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