The separation of ethyl acetate-methanol-water via the extractive distillation process as a chemical process safety simulation experiment is proposed in this paper by combining the chemical process simulation and intrinsic safety. The suitable entrainer with good separation performance is determined via the thermodynamic topology theory. The triple-column extractive distillation process model is constructed for separating the ternary azeotropic mixture ethyl acetate-methanol-water based on the process simulation software Aspen Plus. The developed process is optimized via the multi-objective particle swarm optimization algorithm with economic and safety performances as the objective functions. This simulation training experiment integrates professional courses such as chemical thermodynamics, chemical principles and thermal risk assessment of chemical processes. At the same time, it combines professional theoretical knowledge, cutting-edge disciplinary knowledge and engineering practice application to strengthen basic knowledge, motivate students' research interest and comprehensively improves their innovation ability.