Tactile feedback is crucial for enhancing the virtual-reality (VR) interaction experience. However, current electrotactile devices suffer from issues such as current diffusion and electrode crosstalk, limiting spatial accuracy. To address this challenge, we designed a fabric-based ultrathin flexible microelectrode array with novel stimulation–inhibition electrode units that reduces current diffusion and improves focusing, improving tactile feedback accuracy and clarity. Additionally, we developed an electrical tactile interaction evaluation system to quantitatively assess the tactile recognition accuracy and reaction time of 30 participants. Experimental results demonstrate that the proposed electrode structure and evaluation system substantially enhance tactile perception in VR environments. This system has been demonstrated through immersive scenarios such as touching running water, stroking a bird’s forehead, and feeling a cactus, highlighting its potential for providing precise tactile feedback and enhancing personalized human–computer interaction in VR.

Organic electrochemical transistors (OECTs) exhibit significant potential for applications in healthcare and human-machine interfaces, due to their tunable synthesis, facile deposition, and excellent biocompatibility. Expanding OECTs to the flexible devices will significantly facilitate stable contact with the skin and enable more possible bioelectronic applications. In this work, we summarize the device physics of flexible OECTs, aiming to offer a foundational understanding and guidelines for material selection and device architecture. Particular attention is paid to the advanced manufacturing approaches, including photolithography and printing techniques, which establish a robust foundation for the commercialization and large-scale fabrication. And abundantly demonstrated examples ranging from biosensors, artificial synapses/neurons, to bioinspired nervous systems are summarized to highlight the considerable prospects of smart healthcare. In the end, the challenges and opportunities are proposed for flexible OECTs. The purpose of this review is not only to elaborate on the basic design principles of flexible OECTs, but also to act as a roadmap for further exploration of wearable OECTs in advanced bio-applications.