Organoid technology has emerged as a paradigm-shifting platform in developmental biology, disease modeling, and regenerative medicine. Research progress has outpaced efforts at standardizing reporting of organoid experiments. Heterogeneity of donor characteristics, culture conditions, and assay design remains to complicate reproducibility and limit integration of data between laboratories and repositories. Without harmonization of reporting, the translational value of organoid systems is compromised. To fulfill this requirement, we propose the Minimum Information about Organoid Research (MIOR) framework. MIOR is adapted to serve the unique requirements of organoid research, such as cellular heterogeneity, three-dimensional structure, and multimodal output. The framework offers a modular design in six modules: Project/Dataset, Source, Organoid Characterization & Quality Control, Culture & Manipulation, Integrated Engineering Strategies, and Experimental Assay & Data. These types are delineated as required for fundamental reproducibility and comparability or proposed to provide greater context and interpretability. By creating an enforceable and usable standard, MIOR enhances reproducibility, facilitates data interoperability, and maximizes the translational validity of organoid research. Use of MIOR will transform organoid datasets from one-time products into reusable, combinable materials, and accelerate discovery and clinical translation.
Publications
- Article type
- Year
Article type
Year
Open Access
Editorial
Online First
Cell Organoid
Published: 14 November 2025
Downloads:222
Open Access
Comment
Issue
Cell Organoid 2025, 1(1): 9410012
Published: 13 May 2025
Downloads:232
Open Access
Meeting Report
Issue
Cell Organoid 2025, 1(2): 9410011
Published: 21 April 2025
Downloads:207
Open Access
Editorial
Issue
Cell Organoid 2025, 1(1): 9410000
Published: 26 June 2024
Downloads:149
Total 4
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