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Minimum Information about Organoid Research (MIOR): a framework for reproducibility, interoperability, and translation
Cell Organoid
Published: 14 November 2025
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Organoid technology has emerged as a paradigm-shifting platform in developmental biology, disease modeling, and regenerative medicine. Research progress has outpaced efforts at standardizing reporting of organoid experiments. Heterogeneity of donor characteristics, culture conditions, and assay design remains to complicate reproducibility and limit integration of data between laboratories and repositories. Without harmonization of reporting, the translational value of organoid systems is compromised. To fulfill this requirement, we propose the Minimum Information about Organoid Research (MIOR) framework. MIOR is adapted to serve the unique requirements of organoid research, such as cellular heterogeneity, three-dimensional structure, and multimodal output. The framework offers a modular design in six modules: Project/Dataset, Source, Organoid Characterization & Quality Control, Culture & Manipulation, Integrated Engineering Strategies, and Experimental Assay & Data. These types are delineated as required for fundamental reproducibility and comparability or proposed to provide greater context and interpretability. By creating an enforceable and usable standard, MIOR enhances reproducibility, facilitates data interoperability, and maximizes the translational validity of organoid research. Use of MIOR will transform organoid datasets from one-time products into reusable, combinable materials, and accelerate discovery and clinical translation.

Open Access Comment Issue
The imperative of establishing a national organoid database: strategic autonomy and AI-driven innovation
Cell Organoid 2025, 1(1): 9410012
Published: 13 May 2025
Abstract PDF (285.6 KB) Collect
Downloads:232
Open Access Meeting Report Issue
Advancing precision medicine: strategies from organoids research
Cell Organoid 2025, 1(2): 9410011
Published: 21 April 2025
Abstract PDF (424.8 KB) Collect
Downloads:207
Open Access Editorial Issue
Unveiling Cell Organoid: A vanguard in organoid research
Cell Organoid 2025, 1(1): 9410000
Published: 26 June 2024
Abstract PDF (271.9 KB) Collect
Downloads:149
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