Perovskite solar cells (PSCs) have exhibited impressive performance, achieving a power conversion efficiency (PCE) of 26.1%. However, the water-soluble and toxic nature of lead (Pb) in PSCs hinders their industrialization. Pb chemisorption has emerged as a promising approach to address this issue to prevent Pb leakage and ensure long-term stability. This perspective provides a comprehensive overview of recent advancements in Pb chemisorption in PSCs and discusses the prospects for future developments and challenges in this field.