Many space missions require the execution of large-angle attitude slews during which stringent pointing constraints must be satisfied. For example, the pointing direction of a space telescope must be kept away from directions to bright objects, maintaining a prescribed safety margin. In this paper we propose an open-loop attitude control algorithm which determines a rest-to-rest maneuver between prescribed attitudes while ensuring that any of an arbitrary number of body-fixed directions of light-sensitive instruments stays clear of any of an arbitrary number of space-fixed directions. The approach is based on an application of a version of Pontryagin’s Maximum Principle tailor-made for optimal control problems on Lie groups, and the pointing constraints are ensured by a judicious choice of the cost functional. The existence of up to three first integrals of the resulting system equations is established, depending on the number of light-sensitive and forbidden directions. These first integrals can be exploited in the numerical implementation of the attitude control algorithm, as is shown in the case of one light-sensitive and several forbidden directions. The results of the test cases presented confirm the applicability of the proposed algorithm.