With the continuous development of Internet of Things technology, various work scenarios have higher requirements for real-time communication between devices. This paper designs a temperature and humidity monitoring system for garlic cold storage, using ZigBee wireless communication technology and the function of serial port transfering to wireless of ESP8266 to realize the real-time collection of temperature and humidity data of garlic during storage. Through the interconnection of Aliyun database RDS with PC and mobile applications, the record of temperature and humidity information in the whole cycle of garlic cold storage is completed, and the function of real-time notification of cold storage alarm information without time and location restrictions is realized. The field experiment is designed and implemented based on the system, and the experimental results show that the operating performance of the system is stable.