As trust becomes increasingly important in software domain, software trustworthiness — as a complex high-composite concept, has developed into a big challenge people have to face, especially in the current open, dynamic and ever-changing Internet environment. Furthermore, how to recognize and define trust problem from its nature and how to measure software trustworthiness correctly and effectively play a key role in improving users’ trust in choosing software. Based on trust theory in the field of humanities and sociology, this paper proposes a measurable S2S (Social-to-Software) software trustworthiness framework, introduces a generalized indicator loss to unify three parts of trustworthiness result, and presents a whole metric solution for software trustworthiness, including the advanced J-M model based on power function and time-loss rate for ability trustworthiness measurement, the fuzzy comprehensive evaluation advanced-model considering effect of multiple short boards for basic standard trustworthiness, and the identity trustworthiness measurement method based on the code homology detecting tools. Finally, it provides a case study to verify that the solution is applicable and effective.