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Open Access Correspondence Issue
Authors’ response to correspondence regarding “Application of deep brain stimulation and transcranial magnetic stimulation in stroke neurorestoration: A review”
Journal of Neurorestoratology 2024, 12(4): 100161
Published: 22 October 2024
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Open Access Review Issue
Application of deep brain stimulation and transcranial magnetic stimulation in stroke neurorestoration: A review
Journal of Neurorestoratology 2024, 12(2): 100120
Published: 18 April 2024
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Stroke is a global cause of death and neurological disability. Survivors of stroke experience impaired quality of life because of post-stroke motor disorders, which are the primary driver of stroke-associated healthcare expenditures. Neuromodulatory techniques offer a promising avenue for addressing these post-stroke motor disorders. Post-stroke motor disorders are thought to be related to ongoing maladaptive responses and abnormal brain network reorganization; this offers insights into the inadequacy of most current treatments. In the present review, we summarize the following models involved in post-stroke motor disorders: the dual-pathway model of the basal ganglia, the cerebrocerebellar model, and the interhemispheric inhibition model. By identifying these critical elements, it will be clinically possible to explore mechanism-based therapeutics. On the basis of this physiological understanding, we review progress in the clinical application of the main therapeutic modalities; namely, invasive deep brain stimulation (DBS) and noninvasive transcranial magnetic stimulation (TMS), both of which are currently under investigation for neuromodulation in stroke. Both DBS and TMS are approved by the Food and Drug Administration because of their safety and efficacy. Although little is known about their underlying molecular mechanisms, recent studies have indicated that DBS and TMS promote post-stroke neurogenesis and neuroplasticity, suggesting potential pathways for restoring post-stroke motor disorders. Moreover, we focus specifically on the interactions between TMS and DBS, and discuss the ways in which combined DBS and TMS—for the future personalization of treatment strategies—will further ameliorate post-stroke motor disorders. For example, TMS can be used safely in movement disorder patients with DBS, and pairing DBS with TMS at specific intervals and patterns produces long-term potentiation-like effects related to cortical plasticity. A further characterization of the precise repair mechanisms, together with technological innovations, is likely to substantially improve the efficacy of treatments for post-stroke motor disorders.

Open Access Review Issue
Roles of Eph/ephrin signaling pathway in repair and regeneration for ischemic cerebrovascular and cardiovascular diseases
Journal of Neurorestoratology 2023, 11(1): 100040
Published: 17 December 2022
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Ischemic cerebrovascular and cardiovascular diseases in brain and heart tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, hypertension, etc. Have been increasing in morbidity and mortality in the middle-aged and elderly population over several years. In recent years, the Eph/ephrin signaling pathway has been found to have a major role in the processes of neurogenesis, synaptic plasticity, and angiogenesis, which is likely a key pathway in the modulation of neurological and cardiac functions. Therefore, an in-depth understanding of the role of the Eph/Ephrin signaling pathway in pathophysiological processes will be the emphasis of future research. In ischemic cardiovascular and cerebrovascular diseases, in particular, the development of effective treatment to modulate the Eph/Ephrin signaling pathway to promote neural and vascular repair and regeneration is of great clinical significance and social value. In this study, the role of the Eph/ephrin signaling pathway in ischemic cerebrovascular and cardiovascular diseases is reviewed.

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