The last decade has witnessed a surge of interest in artificial neural network in many different areas of scientific research. Despite the rapid expansion in the application of neural networks, few efforts have been carried out to introduce such a powerful tool into lubrication studies. Thus, this work aims to apply the physics-informed neural network (PINN) to the hydrodynamic lubrication analysis. The 2D Reynolds equation is solved. The PINN is a meshless method and does not require big data for network training compared with classical methods. Our results are consistent with those obtained by experiments and the finite element method. Hence, we envision that the PINN method will have great application potential in lubrication and bearing research.