Scholar - SciOpen

The separation of electron-hole pairs while inhibiting their recombination under ultrasound irradiation is vital phenomena to the generation of reactive oxygen species (ROS) in sonodynamic therapy (SDT). With this bearing in mind, we have designed and synthesized nano heterostructure of FeMoO_y and MoS_x (FeMoO_y@MoS_x, FMOS), featuring a MoS_x nanoflower core, via a two-step hydrothermal process. This structure is subsequently enveloped with cell membrane to form FMOS@cell membrane (FMOS@CM) nano-sonosensitizer. The growth of FeMoO_y on MoS_x effectively narrows the bandgap of MoS_x and facilitates the separation of ultrasound-activated electrons and holes, which significantly enhances SDT performance under ultrasonic irradiation. Additionally, the material harnesses ultrasonic energy to activate surface electrons, converting Fe³⁺ to Fe²⁺. This conversion increases charge utilization efficiency, promotes the activity of Fenton reaction, and optimizes the chemodynamic therapy (CDT) performance of the material. Moreover, the encapsulation within the cell membrane guarantees the tumor-targeting capability and biocompatibility of FMOS@CM, thereby facilitating a more effective and safer tumor treatment strategy. In conclusion, this study presents a novel methodology for synthesizing sonosensitizers by in situ growth-induced assembly of metal ions. This approach provides innovative insights for the development of a new, precise, high-efficiency, multimodal synergistic treatment platform mediated by ultrasound.

Open Access Original Article Issue

Identification of publication characteristics and research trends in the management of gallbladder cancer

Jiasheng Cao, Jiahao Hu, Jiliang Shen, Bin Zhang, Win Topatana, Shijie Li, Tianen Chen, Sarun Jeungpanich, Yitong Tian, Ziyi Lu, Shuyou Peng, Xiujun Cai, Mingyu Chen

iLIVER 2022, 1(2): 127-138

Published: 14 July 2022

Abstract

PDF (3.2 MB) Collect Collected

Downloads：21

Background

To date, no comprehensive analysis of gallbladder cancer (GBC) management has been reported. We aimed to identify the publication characteristics and research trends in managing GBC over the past three decades.

Methods

We selected the 100 most cited articles and performed a bibliometric analysis to summarize the publication characteristics, explore research hotspots, and identify research trends in the management of GBC.

Results

The total citations of the included articles ranged from 123 to 1822. Period II (2001–2010) yielded the highest number of included articles, whereas the lowest was in Period III (2011–2020). The United States and Japan published the most papers, in which the Memorial Sloan–Kettering Cancer Center and Nagoya University were the leading institutions, respectively. The most influential authors were Blumgart LH and Fong YM from the United States. Cooperation among countries, institutions, and authors was weak. The Annals of Surgery contributed the most articles with the highest number of total citations. The most researched topic was surgery, followed by systemic therapy and adjuvant therapy. Since Period I, the percentage of surgery-related publications continuously decreased (Periods II and III versus Period I, both p < 0.001), with a concomitant increase in those of adjuvant therapy (Period III versus Period I, p = 0.004) and systemic therapy (Period II versus Period I, p = 0.004; Period III versus Period I, p = 0.002).

Conclusions

Surgery remains the preferred treatment, while there is a tendency toward adjuvant and systemic therapy in GBC management. An increase in local and international collaboration for managing GBC is required.

Total 2