Medically implantable metallic stents serve as a crucial interventional treatment for vascular stenosis; however, in-stent restenosis persists at a rate of 15%–30% following implantation, substantially compromising therapeutic outcomes. In this study, a composite surface modification strategy combining U-shaped microtextures and dimethyl sulfoxide (DMSO) molecular modification was developed to fabricate novel anticoagulant stents capable of suppressing thrombus regeneration. TC4 titanium alloy (Ti–6Al–4V) vascular stents containing microtextures on the inner surface were prepared by pulsed laser etching, continuous laser welding, and infrared laser engraving. In contrast, the DMSO molecular coating was prepared by the composite chemical modification technique to obtain modified vascular stents with hydrophobic properties, and the exposure of the two CH₃ groups was the reason for the enhanced hydrophobic properties. The results of flow cytometry tests using fluorescein isothiocyanate (FITC)-CD41 antibody and PE-CD62P staining showed that the platelet activation rate on the surface of the microtextured composite DMSO-modified stents was significantly reduced, the CD62P expression rate decreased to 7.74%, and the amount of platelet adhesion was reduced considerably. Hemodynamic analysis demonstrated that, compared to smooth stents, the microtextured stent exhibited reduced shear stress oscillation amplitude along the blood flow wall. The low-shear–stress area (< 0.5 Pa) measured 33.855 mm², a 17.5% reduction, accompanied by effective inhibition of platelet activation.

In this study, micro/nanostructures are fabricated on the surface of 3Cr13 stainless steel via laser etching, and a superhydrophobic coating with silver nanoparticles (AgNPs) is prepared by utilizing the reduction–adsorption properties of polydopamine (PDA). We investigate the effect of soaking time from the "one-step method" on the reduction of nano-Ag, surface wettability, and antibacterial properties. Scanning electron microscopy is performed to analyze the distribution of nano-Ag on the surface, whereas X-ray energy dispersive spectroscopy and X-ray photoelectron spectroscopy are used to analyze the crystal structures and chemical compositions of different surfaces. Samples deposited with PDA on their surface are soaked in a 1H,1H,2H,2H-perfluorodecyltriethoxysilane water–alcohol solution containing AgNO₃ for 3 h. Subsequently, a "one-step method" is used to prepare low-adhesion superhydrophobic surfaces containing AgNPs. As immersion progresses, more AgNPs are deposited onto the surface. Compared with the polished surface, the samples prepared via the "one-step method" show significant antibacterial properties against both gram-negative Escherichia coli and gram-positive Staphylococcus aureus. The antibacterial properties of the surface improve as immersion progresses.