Diabetic wound is a severe complication of diabetes, which significantly impacts clinical management and patient quality of life due to prolonged healing times and increased susceptibility to infections, particularly by antibiotic-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA). Although novel antibiotics have been developed, their clinical use is often limited by suboptimal therapeutic efficacy and significant adverse effects. Herein, we demonstrate the effective elimination of MRSA using nanostructured antimicrobial peptides (nAMPs) derived from Lysine aggregates. The nAMPs are prepared by enriching Lysine on the surface of FeOOH nanoshuttles, which produces FeOOH@Fe-Lysine. The FeOOH@Fe-Lysine nAMPs integrate conventional antibiotic mechanisms with antimicrobial peptide functionalities, targeting bacterial membrane integrity, metabolic pathways, and protein synthesis. Furthermore, the decoration of ultrasmall Au nanoparticles possessing glucose oxidase-like activity enables nAMPs to catalytically produce hydroxyl radicals from glucose, effectively eliminating MRSA and disrupting its biofilms.

Chiral metal nanoclusters (MNCs) are competitive candidates for fabricating circularly polarized light-emitting diodes (CPLEDs), but the device performance is greatly limited by the poor emission of MNCs in solid thin films. Herein, host molecule enhanced aggregation induced emission (AIE) of MNCs is demonstrated for fabricating highly efficient CPLEDs. Namely, on the basis of the AIE effect of atomically precise enantiomeric (R/S)-4-phenylthiazolidine-2-thione capped silver (R/S-Ag₆(PTLT)₆) NCs in solid thin films, 1,3-bis(carbazol-9-yl) benzene (mCP) is introduced as a host molecule to control the orientation and packing arrangements of R/S-Ag₆(PTLT)₆ NCs through π–π interactions with the R/S-Ag₆(PTLT)₆ NCs and further enhance the AIE. The as-fabricated Ag₆(PTLT)₆ NC/mCP hybrid solid thin film shows a high photoluminescence quantum yield of 71.0% close to that of Ag₆(PTLT)₆ NC single crystal. As the hybrid films are employed as the active emission layers of CPLEDs, mCP also suppresses the triplet-triplet annihilation and balances the charge transport. Thus, the CPLEDs exhibit a maximum brightness of 3,906 cd/m², peak external quantum efficiency of 10.0%, and electroluminescence dissymmetry factors of −5.3 × 10⁻³ and 4.7 × 10⁻³.