With unprecedented properties and functions, polymer-based hybrid materials hold extremely important position in many fields. Here in this review, we summarized applications of polymer-based hybrid materials toward personal health. Firstly, theoretical calculation and in-situ visualization used to explore the interfacial interaction and formation of hybrid materials are introduced. Secondly, applications of polymer-based hybrid materials in personal health from proactive protection (anti-bacteria and harmful gas removal), health condition monitoring (breathing and sleep) to disease diagnosis (magnetic resonance imaging), and tissue therapy (dental restoration) are discussed. Additionally, aggregation-induced emission (AIE) organic molecules based optical sensors for personal security and polymer semiconductor for organic thin film transistors are simply discussed. Finally, we present the future tendency for preparing polymer-based hybrid materials that related with personal health.