The development of adaptive emotion regulation (ER) plays a pivotal role in adolescent mental health and socio-emotional adaptation. Dispositional optimism, as an important protective factor for adolescent adjustment, may affect adolescent ER and subsequently influence adaptive outcomes. In this review, the changes and challenges, the role of ER in socio-emotional adjustment, and the developmental characteristics of implicit and explicit ER during adolescence are described. Subsequently, by employing the top-down model of personality, coping, and emotion, how dispositional optimism may affect psychological adjustment from the perspective of ER is analyzed. Furthermore, how the differences in adolescents’ dispositional optimism may be reflected by the differences in implicit ER is discussed. Finally, recommendations for future research are outlined.