More than 60% of cancer patients receive radiation therapy (RT) during their anticancer treatment. However, there is a huge challenge to improve the therapeutic efficacy of RT in less radioresponsive tumors and decrease damages dealt to the surrounding healthy tissues. Herein, we have reported the development of an efficacious RT treatment of relatively radio-resistant breast cancer using W₁₈O₄₉ nanospheres and the second near-infrared (NIR) light irradiation. Featuring the X-ray attenuation ability and photothermal effect, together with ability to generate intracellular singlet oxygen and ·OH, W₁₈O₄₉ nanospheres can significantly increase radiation-induced DNA damage and decrease the mitochondrial membrane potential of cancer cells during RT, causing in nearby three-times improvement in inhibiting the proliferation of 4T1 cells. The in vivo evaluations verify that a rather effective therapeutic outcome is achieved by treatment of 4T1 tumor xenograft with NIR-enhanced RT using W₁₈O₄₉ nanospheres. Moreover, the X-ray attenuation ability and the strong near-infrared absorption of W₁₈O₄₉ nanospheres have enabled highly resolved in vivo computer tomography (CT)/photoacoustic (PA) imaging. This work presents an “all-in-one” synergistic platform to improve the therapeutic efficacy of RT in less radioresponsive tumors, therefore opening a new door for multimodal cancer therapy.

Single site catalysts provide a unique platform for mimicking natural enzyme due to their tunable interaction between metal center and coordinated ligand. However, most works have focused on preparing structural and functional models of nature enzyme, with less reports also taking the local chemical environment, i.e., functional/catalytic residues around the active site which is an essential feature of enzymes, into consideration. Herein, we report a Co-centered porphyrinic polymer containing the enzyme-mimic micro-environment, where the linker triazole over CoN₄ site enables formation of hydrogen bond with the *COOH intermediate, thus promoting the electrocatalytic reduction of CO₂. As-prepared catalyst achieves the CO₂-to-CO conversion of 5, 788 h⁻¹ turnover frequency value and near unit (~ 96%) faradaic efficiency at −0.61 V versus reversible hydrogen electrode. This strategy will bring new dimension of designing highly active single-site catalysts.