As a fundamental course for science and engineering majors in universities, Physical Chemistry has the core mission of imparting systematic professional knowledge and scientific thinking. On this basis, how to organically integrate ideological and political education into the curriculum is a crucial issue that needs to be addressed in course construction. Based on literature analysis, expert interviews, and structured questionnaires, this paper investigates the learning status of some undergraduates in the physical chemistry course.Using a five-point Likert scale, 125 valid samples were analyzed, covering dimensions such as student backgrounds, knowledge mastery, learning adaptability, outcome evaluation, and improvement suggestions. Statistical results reveal multidimensional differences in terms of gender, institutional level, subject selection background, and family education (P < 0.05). Meanwhile, a significant positive correlation was observed between students' knowledge mastery and their ideological-political identification (F=2.685-4.176, P < 0.05). This paper provides empirical evidence for ideological and political construction in science and engineering courses from five aspects: clarifying educational objectives, broadening educational scope, strengthening teaching teams, identifying educational perspectives, and achieving targeted education. It also offers practical references for exploring synergistic paths between professional teaching and value guidance.

In order to study the mechanism of rapid detection of amyloid fibrils and the kinetic and structural properties of the amyloid fibrillation process for early monitoring of Alzheimer' disease (AD), this paper designed an amphiphilic AIE fluorescent probe (E)-1-butyl-4-(4-(diphenylamino)styryl)pyridin-1-ium bromide (BSTI). The BSTI exhibits high binding affinity, high on-off ratio, high photostability and good two-photon excitation fluorescence properties, as well as appropriate molecular weight and the potential to cross the blood-brain barrier. When combined with bovine insulin amyloid fibrils, it exhibits strong NIR emission with an on/off ratio > 100. In addition, BSTI-based two-photon fluorescence imaging of amyloid fibrils also exhibited a high signal-to-noise ratio. Which make BSTI an ideal probe for detecting amyloid fibrils in vivo and early monitoring of AD.

Summarizing the research progress in the design, synthesis, and application fields of boron difluoride complexes can reveal the current hotspots and difficulties in research, provide direction guidance for future research, and expand the application fields of optoelectronic functions. Boron difluoride complexes are currently mainly divided into three categories: N, N-bidentate organic boron difluoride complexes, N, O-bidentate organic boron difluoride complexes, and O, O-bidentate organic boron difluoride complexes. This article systematically reviews the synthesis methods, and applications of these three types of boron difluoride complex functional materials, which will help promote the research and application of new materials, promote interdisciplinary cooperation, and have important scientific significance and application prospects.

The formation of amyloid plaques usually occurs in the early-stage of Alzheimer’s disease (AD). Stimulated emission depletion (STED) imaging provided a powerful tool for visualizing amyloid structures on the nanometer scale. However, many commercial probes adopted in detecting amyloid fibrils are inapplicable to STED imaging, owing to their unmatched absorption and emission wavelengths, small Stokes’ shift, easy photo-bleaching, etc. Herein, we demonstrated a polarity-activated STED probe based on an intramolecular charge transfer donor (D)-π-acceptor (A) compound. The electron-rich carbazole group and the electron-poor pyridinium bromide group, linked by π-conjugated thiophen-bridge, ensure strong near infrared (NIR) emission with a Stokes’ shift larger than 200 nm. The tiny change in polarity before and after binding with amyloid plaques leads to a transition from weakly emission charge-transfer (CT) state (Φ < 0.04) to highly emissive locally-excited (LE) state (Φ = 0.57), giving rise to a fluorescence Turn-On probe. Together with large Stokes’ shift, good photostability and high depletion efficiency, the super-resolution imaging of the formation and morphology of amyloid fibrils in vitro based on this probe was realized with a lateral spatial resolution better than 33 nm at an extremely low depletion power. Moreover, the ex-vivo super-resolution imaging of (E)-1-butyl-4(2-(5-(9-ethyl-9H-carbazol-3-yl)thiophen-2-yl)vinyl) pyridinium bromide (CTPB) probe in Aβ plaques in the brain slices of a Tg mouse was demonstrated. This research provides a demonstration of the super resolution imaging probe of amyloid fibrils based on polarity-response mechanism, providing a new approach to the development of future amyloid probes.