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Open Access Research Article Issue
Effects of chronic stress on nectin1 levels in the mouse primary somatosensory cortex
Stress and Brain 2022, 2 (3): 100-110
Published: 22 September 2022
Downloads:126

Chronic exposure to stressful experiences impairs synaptic plasticity. Previous studies have shown that the spine densities of pyramidal neurons, the turnover of mushroom-type spines, and the excitatory–inhibitory balance in the primary somatosensory cortex (S1) are modulated by stress. Trans-synaptic cell adhesion molecules (CAMs) are implicated in stress-induced synaptic deficits. However, it remains unknown whether stress dysregulates CAMs in S1 and thereby impairs synaptic plasticity. In this study, we applied the early-life stress (ELS), chronic social defeat stress (CSDS), and chronic restraint stress paradigms and measured the mRNA levels of nectin1 in S1 of wild-type and conditional forebrain corticotropin-releasing hormone receptor 1 type (CRHR1) conditional knockout mice. We found that ELS increased nectin1 mRNA levels in S1 in adult but not adolescent mice. Moreover, CSDS increased the nectin1 mRNA levels in S1 in adult mice via the CRH-CRHR1 system. Our findings suggest that S1 is vulnerable to repeated stress exposures at some life stages, and dysregulated nectin1 expression may underlie stress-induced structural and functional abnormalities in S1.

Open Access Review Article Issue
Influence of enriched environment on anxiety-related behavior: evidence and mechanisms
Stress and Brain 2021, 1 (1): 33-45
Published: 07 March 2021
Downloads:199
total 2