Preparation and Characterization of Nanoparticulate Drug Delivery System for Naproxen Sodium Using Various Desolvating Agents

Huda Syed; Abbaraju Krishna Sailaja

doi:10.5101/nbe.v11i3.p254-263

Nano Biomedicine and Engineering 2019, 11(3): 254-263 https://doi.org/10.5101/nbe.v11i3.p254-263

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Open Access | Issue | Published: 16 August 2019

Preparation and Characterization of Nanoparticulate Drug Delivery System for Naproxen Sodium Using Various Desolvating Agents

Show Author's Information Hide Author's Information Huda Syed, Abbaraju Krishna Sailaja(

)

RBVRR Women's College of Pharmacy, Barkatpura, Hyderabad, India

Keywords:

SEM, Desolvation, Bovine serum albumin, Cross linking agent, Butanol

Cite this article:

Syed H, Sailaja AK. Preparation and Characterization of Nanoparticulate Drug Delivery System for Naproxen Sodium Using Various Desolvating Agents. Nano Biomedicine and Engineering, 2019, 11(3): 254-263. https://doi.org/10.5101/nbe.v11i3.p254-263

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Abstract

Naproxen sodium is a non-steroidal anti-inflammatory agent used for the treatment of autoimmune disorders to relieve pain and inflammation. In the present study, naproxen sodium nanoparticles were prepared by desolvation technique using various desolvating agents (butanol and combinations of acetonitrile and butanol), and two methods (continuous addition method and intermittent addition method) were adapted to decide the best desolvating agent. Obtained formulations were characterized and evaluated. The combination of acetonitrile and butanol as desolvating agent was giving good and promising results with good stability -40.7 mV and least mean particle diameter of 437.7 nm. From the results it was concluded that intermittent addition was the better method than continuous addition method for preparing naproxen sodium nanoparticles. The drug release was sustained till 12 h with 96.92% for nanoparticles prepared by intermittent addition method following zero order release with non- fickian diffusion mechanism.

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Preparation and Characterization of Nanoparticulate Drug Delivery System for Naproxen Sodium Using Various Desolvating Agents

Show Author's information Hide Author's Information Huda Syed, Abbaraju Krishna Sailaja(

)

RBVRR Women's College of Pharmacy, Barkatpura, Hyderabad, India

Abstract

Keywords: SEM, Desolvation, Bovine serum albumin, Cross linking agent, Butanol

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Publication history

Received: 21 June 2019

Accepted: 16 August 2019

Published: 16 August 2019

Issue date: September 2019

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Acknowledgements

The authors sincerely thank Dr. M. Sumakanth, the Principal, RBVRR Women's College of Pharmacy for providing access to the library and databases. We also thank Mrs. Suvarna and Mrs. Sumalatha, for providing technical assistance.

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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.