New strategies for preventing and treating kidney disease with multimorbidity based on the body constitution of traditional Chinese medicine

Multimorbidity is a significant challenge to global public health. In particular, the interaction between metabolic diseases, cardiovascular diseases, and chronic kidney disease further complicates the condition and treatment in patients with kidney diseases. Current strategies for managing multimorbidity often combine treatments for specific diseases passively, which can easily lead to polypharmacy issues. An urgent need exists to break through the theoretical framework of disease-centered medicine, transcend conventional thinking, and explore novel therapeutic strategies. Therefore, this paper proposes that the integration of the kidney zang-xiang theory and the body constitution of traditional Chinese medicine (TCM) would be beneficial for handling this problem. Preventive treatment of disease is a unique advantage of TCM, and the body constitution theory and method ology are essential strategies for preventive medicine in TCM. Holistic views guide the entire process of body constitution and preventive treatment of disease. By subdividing different pre-disease states within the full cycle of health and disease and discovering the regularity of cross-organ progression of the disease and its effect on kidney disease under the guidance of "the soil theory of body constitution," modern nephrology findings can be integrated to tailor comprehensive prevention and treatment plans for different pre-disease states, different types of kidney diseases, and their comorbidity models, thereby addressing the issue of kidney disease with multimorbidity.