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Original Article | Open Access

MiR-145 affects cell cycles by inhibiting cyclin A2 and cyclin dependent kinase 6 in oral squamous cell carcinoma, a progression and prognostic biomarker

Hao Pan1,§, Yuehong Wang2,§, Xinna Bai3, Binjie Liu1, Hongzhi Quan4, Qingwen Zeng1, Jiajia Zeng1, Qian Tang5, Liqun Gu4, Zhiyuan Deng4, Zhigang Yao6, Ousheng Liu7,8( ), Zhangui Tang4( )
Department of Periodontics, Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, 410008, China
Department of Implant Center, Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, 410008, China
Department of Conservative Dentistry & Endodontics, Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, 410008, China
Department of Oral & Maxillofacial Surgery, Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, 410008, China
Department of Pediatric Stomatology, Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, 410008, China
Department of Oral Pathology, Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, 410008, China
Department of Orthodontics, Hunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, 410008, China
FuRong Laboratory, Changsha, 410078, China

§These authors contributed equally to this work.

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Abstract

Identifying novel prognostic markers is crucial for predicting clinical outcomes and guiding targeted therapies. This study explores the biomarker potential of specific miRNAs, particularly miR-145 and miR-21, in the prognosis of oral squamous cell carcinoma (OSCC) and their associated mechanisms. mRNA and miRNA expression profiles were analyzed in OSCC patients. Bioinformatic analysis identified miR-145 and miR-21 as key markers. Clinical data from 87 patients showed that high miR-145 and low miR-21 expression correlated with a 91.6% 5-year survival rate. Functional studies showed that miR-145 induced G0/G1 phase arrest and shortened the S phase in OSCC cells. Overexpressing miR-145 or knocking down cyclin A2 (CCNA2) or cyclin-dependent kinase 6 (CDK6) inhibited OSCC cell proliferation. Dual-luciferase assays confirmed that miR-145 directly targets the 3′-UTRs of CCNA2 and CDK6, reducing their expression. MiR-145, particularly when combined with miR-21, is a promising OSCC prognostic biomarker. It exerts its effects by modulating the cell cycle via CCNA2 and CDK6 suppression.

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Keywords

oral squamous cell carcinomamiR-145miR-21prognostic biomarkerCCNA2CDK6

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Oral Science and Homeostatic Medicine
Volume 1 Issue 2,
September 2025
Article number: 9610002
DOI: 10.26599/OSHM.2025.9610002

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Cite this article:
Pan H, Wang Y, Bai X, et al. MiR-145 affects cell cycles by inhibiting cyclin A2 and cyclin dependent kinase 6 in oral squamous cell carcinoma, a progression and prognostic biomarker. Oral Science and Homeostatic Medicine, 2025, 1(2): 9610002. https://doi.org/10.26599/OSHM.2025.9610002

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Received: 05 January 2025
Revised: 23 January 2025
Accepted: 04 March 2025
Published: 09 April 2025
© The Author(s) 2025. Published by Tsinghua University Press.

This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the original author(s) and the source, provide a link to the license, and indicate if changes were made. See https://creativecommons.org/licenses/by/4.0/