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Nano TransMed 2022, 1(2–4): e9130007 https://doi.org/10.26599/NTM.2022.9130007
Review Article | Open Access | Issue | Published: 08 September 2022

Application of telomere biology and telomerase in mesenchymal stem cells

Show Author's Information Shuili Jing1,§,  Heng Zhou1,§,  Chen Zou2,§,  David P. C. Chen3,  Qingsong Ye1( ),  Yilong Ai2( ),  Yan He4( )
Center of Regenerative Medicine & Department of Stomatology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Foshan Hospital of Stomatology, School of Medicine, Foshan University, Foshan 528225, China
School of Dentistry, University of Queensland, Herston, QLD 4006, Australia
Institute of Regenerative and Translational Medicine, Tianyou Hospital of Wuhan University of Science and Technology, Wuhan 430064, China

§ Shuili Jing, Heng Zhou, and Chen Zou contributed equally to this work.

Keywords:
nanoprobe, mesenchymal stem cells (MSCs), senescence, telomere biology, telomerase
Cite this article:
Jing S, Zhou H, Zou C, et al. Application of telomere biology and telomerase in mesenchymal stem cells. Nano TransMed, 2022, 1(2–4): e9130007. https://doi.org/10.26599/NTM.2022.9130007
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Abstract Full text About this article

With the increasing understanding of mesenchymal stem cells (MSCs), their potential in tissue engineering and regenerative medicine has attracted more attention. However, some important problems need to be solved before clinical application, such as low amplification efficiency, inconsistent cell product quality, and unsatisfactory survival rate at the receptor site. Telomeres act as a clock, and they shorten when cells divide. The main mechanism for reversing telomere length is telomerase. Furthermore, telomerase is involved in antioxidation, antiapoptosis, immunological modulation, and other noncanonical processes in addition to proliferation-related tasks. Therefore, it is necessary to understand the telomere biology and telomerase of MSCs to improve their proliferation, performance stability, and antiscavenging ability. This review summarizes the progress of telomerase biological function and mechanism in MSCs, and discusses the current situation and deficiency of telomerase-related application in MSCs.


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About this article

Application of telomere biology and telomerase in mesenchymal stem cells

Show Author's information Shuili Jing1,§, Heng Zhou1,§, Chen Zou2,§, David P. C. Chen3, Qingsong Ye1( ), Yilong Ai2( ), Yan He4( )
Center of Regenerative Medicine & Department of Stomatology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Foshan Hospital of Stomatology, School of Medicine, Foshan University, Foshan 528225, China
School of Dentistry, University of Queensland, Herston, QLD 4006, Australia
Institute of Regenerative and Translational Medicine, Tianyou Hospital of Wuhan University of Science and Technology, Wuhan 430064, China

§ Shuili Jing, Heng Zhou, and Chen Zou contributed equally to this work.

Abstract

With the increasing understanding of mesenchymal stem cells (MSCs), their potential in tissue engineering and regenerative medicine has attracted more attention. However, some important problems need to be solved before clinical application, such as low amplification efficiency, inconsistent cell product quality, and unsatisfactory survival rate at the receptor site. Telomeres act as a clock, and they shorten when cells divide. The main mechanism for reversing telomere length is telomerase. Furthermore, telomerase is involved in antioxidation, antiapoptosis, immunological modulation, and other noncanonical processes in addition to proliferation-related tasks. Therefore, it is necessary to understand the telomere biology and telomerase of MSCs to improve their proliferation, performance stability, and antiscavenging ability. This review summarizes the progress of telomerase biological function and mechanism in MSCs, and discusses the current situation and deficiency of telomerase-related application in MSCs.

Keywords: nanoprobe, mesenchymal stem cells (MSCs), senescence, telomere biology, telomerase

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Publication history

Received: 02 June 2022
Accepted: 01 July 2022
Published: 08 September 2022
Issue date: December 2022

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© The Author(s) 2022. Nano TransMed published by Tsinghua University Press.

Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 81871503 from Qingsong Ye) and Chutian Researcher Project (No. X22020024 from Yan He).

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