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The Correlation between Osteoporotic Vertebral Fracture and Paravertebral Muscle Condition and Its Clinical Treatment
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Osteoporotic vertebral fracture (OVF) is a common complication in patients with osteoporosis. The quality and functional status of the muscles around the spine are one of the important factors influencing the occurrence of OVF. Muscles play a role in both the mechanical and chemical interactions with adjacent bones. The muscles surrounding the spine influence the macrostructure and microstructure of spinal vertebrae through various mechanisms to protect and maintain the stability and strength of the spine. However, abnormal muscle quality and function can have a negative impact on the vertebrae. Screening for muscle quality and function in individuals at risk of OVF using radiographic, physical, and other biochemical methods can be employed for secondary prevention. Meanwhile, utilizing various increasingly mature novel nanomolecular technologies can have a positive impact on the treatment of OVF and vertebral strength, mitigating the clinical consequences of OVF onset.
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The Correlation between Osteoporotic Vertebral Fracture and Paravertebral Muscle Condition and Its Clinical Treatment
)
Abstract
Osteoporotic vertebral fracture (OVF) is a common complication in patients with osteoporosis. The quality and functional status of the muscles around the spine are one of the important factors influencing the occurrence of OVF. Muscles play a role in both the mechanical and chemical interactions with adjacent bones. The muscles surrounding the spine influence the macrostructure and microstructure of spinal vertebrae through various mechanisms to protect and maintain the stability and strength of the spine. However, abnormal muscle quality and function can have a negative impact on the vertebrae. Screening for muscle quality and function in individuals at risk of OVF using radiographic, physical, and other biochemical methods can be employed for secondary prevention. Meanwhile, utilizing various increasingly mature novel nanomolecular technologies can have a positive impact on the treatment of OVF and vertebral strength, mitigating the clinical consequences of OVF onset.
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Acknowledgements
This work was supported by the Wu Jieping Medical Foundation (Project No. 320.6750.19089– 40; 320.6750.2022– 11-50), Jilin Province Science and Technology Development Plan (Project No. 20220203113SF), State Key Laboratory of Electroanalytical Chemistry Open Project Fund (Project No. SKLEAC202101).
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