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Research Article | Open Access

In vivo Antioxidant Potential of Biogenic Silver Nanoparticles Synthesized from Psidium guajava L.

Atif Yaqub1( ), Muhammad Rashid1, Sarwar Allah Ditta1, Naila Malkani1, Nazish Mazhar Ali1, Muhammad Zubair Yousaf2, Arslan Haider1, Muhammad Jamil Yousaf3, Saman Abdullah1
Department of Zoology, Government College University, Lahore 54000, Pakistan
School of Life Sciences, Forman Christian College University, Lahore 54600, Pakistan
Higher Education Department, Government of the Punjab, Lahore 54000, Pakistan
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Abstract

Excessive utilization of nanoparticles renders it necessary to produce safer and more secure nanoparticles while preserving their efficacy. In this study, Psidium guajava L. pulp extract-mediated silver nanoparticles (AgNPs) were synthesized, characterized, and further evaluated regarding their antioxidant potential. The green synthesized silver nanoparticles (G-AgNPs) showed a higher level of radical scavenging activity (RSA) (25.85%), hydrogen peroxide scavenging activity (34.34%), and ferric reducing power (0.28). The comparison of the control group (G1) with the various treatment groups (G2–G6) revealed that the levels of catalase (CAT), superoxide dismutase (SOD), and glutathione-S-transferase (GST) were significantly different (P < 0.05). The levels of blood urea, uric acid, blood urea nitrogen (BUN), serum glutamic pyruvic transaminase (SGTP), serum creatinine, serum glutamic-oxaloacetic transaminase (SGOT), alkaline phosphatase, total bilirubin, and serum electrolytes were also evaluated. The results of clinical biochemistry also strengthened our hypothesis that G-AgNPs are less toxic than C-AgNPs. Finally, the histopathology of liver, kidney, and intestinal tissues indicated that green-synthesized AgNPs are relatively safer.

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Keywords

silver nanoparticles (AgNPs)safer nanoparticlescatalaseoxidative stressacute toxicitynanotoxicity

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Nano Biomedicine and Engineering
Volume 15 Issue 3,
September 2023
Pages 225-238
DOI: 10.26599/NBE.2023.9290026

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Cite this article:
Yaqub A, Rashid M, Ditta SA, et al. In vivo Antioxidant Potential of Biogenic Silver Nanoparticles Synthesized from Psidium guajava L.. Nano Biomedicine and Engineering, 2023, 15(3): 225-238. https://doi.org/10.26599/NBE.2023.9290026

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Received: 08 April 2023
Revised: 04 June 2023
Accepted: 16 June 2023
Published: 10 August 2023
© The Author(s) 2023.

This is an open-access article distributed under  the  terms  of  the  Creative  Commons  Attribution  4.0 International  License (CC BY) (http://creativecommons.org/licenses/by/4.0/), which  permits  unrestricted  use,  distribution,  and reproduction in any medium, provided the original author and source are credited.