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Food Science and Human Wellness 2024, 13(3): 1311-1321 https://doi.org/10.26599/FSHW.2022.9250110
Research Article | Open Access | Issue | Published: 08 February 2024

Influence of soaking Malus domeri (Bois) Chev. leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city, Guangxi, China

Show Author's Information Hui Niea,b,  Zhongyang Gaoa,b,  Yanghe Luoc,  Yajuan Wanga,b,  Feiyang Wua,b,  Guangqing Mua,b( ),  Xiaomeng Wua,b,( )
School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China
Dalian Probiotic Function Research Key Laboratory, Dalian Polytechnic University, Dalian 116034, China
Guangxi Key Laboratory of Health Care Food Science and Technology, Hezhou University, Hezhou 542899, China

Peer review under responsibility of Tsinghua University Press.

Keywords:
Gut microbiota, Longevity, Metabolomics, Malus domeri (Bois) Chev. leaves
Cite this article:
Nie H, Gao Z, Luo Y, et al. Influence of soaking Malus domeri (Bois) Chev. leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city, Guangxi, China. Food Science and Human Wellness, 2024, 13(3): 1311-1321. https://doi.org/10.26599/FSHW.2022.9250110
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Abstract Full text Electronic supplementary material About this article

To investigate the effects of drinking the soaking of Malus domeri (Bois) Chev. leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city, Guangxi, China. It has been reported that longevity is closely related to metabolism and the gut microbiota. The 16S rRNA sequencing and liquid chromatography-mass spectrometry (LC-MS) were used to analysis fecal samples and explore the factors affecting longevity in the region. Interestingly, we discovered, that elderly individuals who had been drinking the soaking of M. domeri (Bois) Chev. leaves for a long time exhibited higher diversity of the gut microbiota than without drinking the soaking, notably. The proportions of Ruminococcaceae and Prevotella were decreased in those who did not drink this soaking. In addition, a total of 106 metabolites were characterized, and the people of long-lived people (> 90 years old) and elderly people (< 90 years old) who drinking soaking of M. domeri (Bois) Chev. leaves signif icantly altered the gut microbiota and upregulate d levels of haplopine, farnesol, genipic acid, momordicinin, 2-hydroxyestrone, hydroxyphenyllactic acid, caffeic acid, sophoraflavanone B, and soyasaponin I. We preliminarily determined that M. domeri (Bois) Chev. leaves consumption may be an important factor affecting longevity in this area.


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Abstract
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Electronic supplementary material
About this article

Influence of soaking Malus domeri (Bois) Chev. leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city, Guangxi, China

Show Author's information Hui Niea,b, Zhongyang Gaoa,b, Yanghe Luoc, Yajuan Wanga,b, Feiyang Wua,b, Guangqing Mua,b( ), Xiaomeng Wua,b,( )
School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China
Dalian Probiotic Function Research Key Laboratory, Dalian Polytechnic University, Dalian 116034, China
Guangxi Key Laboratory of Health Care Food Science and Technology, Hezhou University, Hezhou 542899, China

Peer review under responsibility of Tsinghua University Press.

Highlights

• The gut microbiota of Hezhou long-lived people were analyzed for the first time.

• Drinking the soaking of Malus domeri (Bois) Chev. leaves regulated the gut microbial composition.

• A total of 106 metabolites were detected in fecal samples of long-living elderly individuals.

Abstract

To investigate the effects of drinking the soaking of Malus domeri (Bois) Chev. leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city, Guangxi, China. It has been reported that longevity is closely related to metabolism and the gut microbiota. The 16S rRNA sequencing and liquid chromatography-mass spectrometry (LC-MS) were used to analysis fecal samples and explore the factors affecting longevity in the region. Interestingly, we discovered, that elderly individuals who had been drinking the soaking of M. domeri (Bois) Chev. leaves for a long time exhibited higher diversity of the gut microbiota than without drinking the soaking, notably. The proportions of Ruminococcaceae and Prevotella were decreased in those who did not drink this soaking. In addition, a total of 106 metabolites were characterized, and the people of long-lived people (> 90 years old) and elderly people (< 90 years old) who drinking soaking of M. domeri (Bois) Chev. leaves signif icantly altered the gut microbiota and upregulate d levels of haplopine, farnesol, genipic acid, momordicinin, 2-hydroxyestrone, hydroxyphenyllactic acid, caffeic acid, sophoraflavanone B, and soyasaponin I. We preliminarily determined that M. domeri (Bois) Chev. leaves consumption may be an important factor affecting longevity in this area.

Keywords: Gut microbiota, Longevity, Metabolomics, Malus domeri (Bois) Chev. leaves

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Received: 19 June 2022
Revised: 07 October 2022
Accepted: 11 December 2022
Published: 08 February 2024
Issue date: May 2024

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© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

Acknowledgements

Acknowledgements

This project was supported by the National Natural Science Foundation of China (32072193) and the Natural Science Foundation of Guangxi, China (2020GXNSFBA297083).

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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