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Review Article | Open Access

Motherwort: a mechanistic review on its health benefits of multiple-organ injury

Zi-Tong Qin1,†, Hong-Min Yu1,†, Kelly Yinching Lam2, Han-Zhi Chen1, Qian-Yuan Wu1, Ying-Zheng Wang1( ), Ying-Hao Wang1( )
College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350000, China
School of Chinese Medicine, Hong Kong Baptist University, Kowloon City, Hong Kong 999077, China

† Zi-Tong Qin and Hong-Min Yu contributed equally to this work.

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Highlights

(1) This review covers the five major chemical classes of Leonurus japonicus and details the structures and pharmacological activities of its 34 key constituents.

(2) It systematically elaborates on the origin, medicinal history, and clinical pharmacology research progress of Leonurus japonicus through October 2024.

(3) This traditional Chinese medicine holds significant potential for treating multiple organ diseases and is expected to demonstrate broader organ-protective effects through further in-depth studies.

Abstract

Leonurus japonicus (motherwort) is included in China's List of Medicinal and Food Homologous Substances, thereby permitting its use as a health food and highlighting its significant potential for development in the application of herbal cuisine. At the same time, as an integral herb within the traditional Chinese medicine (TCM) repertoire, it has been extensively utilized for the amelioration of various clinical maladies since antiquity. Due to the great variety of active components and the wide range of pharmacological action, motherwort has garnered significant research attention. By summarizing and comparing the research on motherwort in recent years, this treatise has meticulously examined the chemical constituents and their safeguarding effects on the heart, kidneys, liver, and uterus, with the aspiration of offering valuable insights for subsequent clinical utilization and health functional food development of this herb.

Graphical Abstract

Leonurus japonicus (motherwort) is incorporated into the catalogue of homology of medicine and food in China, thereby permitting its use as a health food and highlighting its significant potential for development in the application of herbal cuisine. At the same time, as an integral herb within the Traditional Chinese Medicine (TCM) repertoire, it has been extensively utilized for the amelioration of various clinical maladies since antiquity. Due to the great variety of active components and the wide range of pharmacological action, motherwort has been widely concerned. By summarizing and comparing the research on motherwort in recent years, this treatise has meticulously examined the chemical constituents and their safeguarding effects on the heart, kidneys, liver, and uterus, with the aspiration of offering valuable insights for subsequent clinical utilization and health functional food development of this herb.

Keywords

motherwortchemical compositionmultiple-organ protection

References

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Food & Medicine Homology
Volume 3 Issue 3,
September 2026
Article number: 9420117
DOI: 10.26599/FMH.2026.9420117

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Cite this article:
Qin Z-T, Yu H-M, Lam KY, et al. Motherwort: a mechanistic review on its health benefits of multiple-organ injury. Food & Medicine Homology, 2026, 3(3): 9420117. https://doi.org/10.26599/FMH.2026.9420117

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Web of Science
Received: 10 October 2024
Revised: 25 November 2024
Accepted: 07 December 2024
Published: 20 November 2025
© National R & D Center for Edible Fungus Processing Technology 2026. Published by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).