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Review Article | Open Access

Pharmacological Properties of Atractylodes macrocephala Koidz.: A Comprehensive Review

Jiang-Bao Wang2,†, Lu Wang3,†, Song-Hong Yang1( )
School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China
School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China
Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Sciences, Ourense 32004, Spain

† Jiang-Bao Wang and Lu Wang contributed equally to this work.

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Highlights

(1) AMK, as a traditional qi-invigorating medicine, has extremely high value of both medicine and food, and its pharmacological research is very important.

(2) In this review, botanical characteristics, phytochemistry, pharmacology, pharmacokinetics of AMK were comprehensively analyzed and summarized.

(3) By consolidating current research, this review seeks to offer a thorough reference for the practical application, development and utilization of AMK as a food with homology of medicine and food.

Abstract

Atractylodes macrocephala Koidz. (AMK), commonly known as Baizhu, is a medicinal and edible plant. Researchers have identified over 77 metabolites in AMK. Many studies have demonstrated the diverse pharmacological activities of AMK, including enhancing gastrointestinal function; modulating immune responses; regulating hormonal secretion; and exerting antitumor, anti-inflammatory, antiaging, antioxidant, antiosteoporotic, antibacterial, and neuroprotective effects.

Graphical Abstract

Major active components, pharmacological activities and traditional records of AMK. Major active component of the figure contain Triterpenoids Sesquiterpenoids, Coumarins, Phenylpropanoids and Polyacetylenes. Pharmacological activities contain Neuroprotection, Anti-Inflammation and Gastrointestinal Function.

Keywords

Atractylodes macrocephala Koidz.pharmacological activitiesactive ingredients

References

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Food & Medicine Homology
Volume 3 Issue 2,
June 2026
Article number: 9420089
DOI: 10.26599/FMH.2026.9420089

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Cite this article:
Wang J-B, Wang L, Yang S-H. Pharmacological Properties of Atractylodes macrocephala Koidz.: A Comprehensive Review. Food & Medicine Homology, 2026, 3(2): 9420089. https://doi.org/10.26599/FMH.2026.9420089

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Received: 07 September 2024
Revised: 06 December 2024
Accepted: 06 December 2024
Published: 18 February 2025
© National R & D Center for Edible Fungus Processing Technology 2025. Published by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).