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Article | Open Access

Harnessing fuzzy logic framework to quantify diagnostic uncertainty in medical decision support

Department of AI&DS, Panimalar Engineering College, Chennai 600123, India.
Department of Information Technology, Dr. Mahalingam College of Engineering and Technology, Pollachi 642003, India.
Department of Computer Science and Engineering (Cyber Security), Dr. N.G.P. Institute of Technology, Tamil Nadu 641048, India.
Department of Computer Science and Engineering, Sri Ramakrishna Institute of Technology, Tamil Nadu 641010, India.
Department of Computer Science and Engineering, Sri Ramakrishna Institute of Technology, Tamil Nadu 641010, India.
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Abstract

Medical diagnosis has become increasingly difficult, requiring sophisticated systems to manage decision-making uncertainty. The proposed medical diagnosis utilizing fuzzy logic framework (MD-FLF) addresses medical data imprecision and ambiguity by employing fuzzy inference techniques. Clinical data ambiguity is often overlooked by conventional diagnosis models. Such models include probabilistic classifiers and threshold-based decision trees. The models use accurate input-output correlations. However, fuzzy inference simplifies incremental membership assignment and rule-based reasoning in MD-FLF. This enhances the system’s diagnostic ambiguity detection. The framework uses fuzzy rules to represent complicated non-linear interactions between symptoms and diagnostic data. This improves framework interpretation. MD-FLF models’ ambiguity and non-linear relationships between diagnostic inputs and outputs provide interpretable recommendations for complex disorders. Rule-based methods and expert knowledge produce these results. Experimental evaluations showed that MD-FLF improved reliability by 97.68%, uncertainty by 96.84%, ambiguity by 43.56%, patient variability by 98.26%, and diagnostic accuracy by 97.82%. The paradigm addresses uncertainty to increase diagnostic reliability, precision, and confidence while eliminating ambiguity and offering clinical decision-making insights. MD-FLF outperforms deterministic techniques in medical diagnostic decision support systems and is stable and interpretable.

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Fuzzy Information and Engineering
Pages 425-445

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Cite this article:
Leelavathy S, Ramprasath J, Mettildha Mary I, et al. Harnessing fuzzy logic framework to quantify diagnostic uncertainty in medical decision support. Fuzzy Information and Engineering, 2025, 17(4): 425-445. https://doi.org/10.26599/FIE.2025.9270070

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Received: 28 January 2025
Revised: 25 March 2025
Accepted: 13 April 2025
Published: 12 December 2025
© The Author(s) 2025.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).