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Review | Open Access

2016 yearbook of neurorestoratology

Hongyun Huang1,2( ), Gengsheng Mao1, Shiqing Feng3, Lin Chen2,4
Institute of Neurorestoratology, General Hospital of Armed Police Forces,
Cell Therapy Center, Beijing Hongtianji Neuroscience Academy, Beijing,
Department of Orthopedic, Tianjin Medical University General Hospital, Tianjin,
Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing, People’s Republic of China
Show Author Information

Abstract

Neurorestoratology, a new interdisciplinary field, has gradually become a popular clinical discipline. Physicians and scientists in the neurorestoration field have discovered new pathogeneses of nervous system diseases and damage, explored new neurorestorative mechanisms, and obtained improving neurorestorative effects in clinical trials (or therapies). This paper summarizes the major progress achieved over the past year.

Keywords

neurorestoratologyyearbookpathogenesisneurorestorative mechanismsneurorestorative strategiesneural repair and regenerationcentral nervous system disease

References

1.
Huang H, Chen L. Neurorestoratology—new subject, new principle, new field in 21st century. J Repar Reconstr Surg. 2008;22:439–445.
Google Scholar
2.
Chen L, Huang H. Neurorestoratology: new concept and bridge from bench to bedside. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi .2009;23:366–370.
Google Scholar
3.
Huang H, Sharma H. Neurorestoratology: one of the most promising new disciplines at the forefront of neuroscience and medicine. J Neurorestoratol .2013;1:37–41.
Crossref Google Scholar
4.
Huang L, Chen L. Neurorestoratology: a concept and emerging discipline in the treatment of neurological disorders. CNS Neurol Disord Drug Targets .2016;15(5):522–525.
Crossref Google Scholar
5.
IANR (International Association of Neurorestoratology). Beijing declaration of international association of neurorestoratology (IANR). Cell Transplant .2009;18:487.
Crossref Google Scholar
6.
Gao J, Thonhoff JR, Dunn TJ, Wu P. Lipoic acid enhances survival of transplanted neural stem cells by reducing transplantation-associated injury. J Neurorestoratol .2013;1:1–12.
Crossref Google Scholar
7.
Young W, AlZoubi Z, Saberi H, et al. Beijing declaration of international association of neurorestoratology (IANR). J Neurorestoratol .2015,3:121–122.
Google Scholar
8.
Cajal SRY. Degeneration and Regeneration of the Nervous System (May RM, Trans.). London: Oxford University Press; 1928.
9.
Huang H, Chen L, Sanberg PR. Clinical achievements, obstacles, falsehoods, and future directions of cell-based neurorestoratology. Cell Transplant .2012;21(Suppl 1):S3–S11.
Crossref Google Scholar
10.
Huang H, Sun T, Chen L, et al. Consensus of clinical neurorestorative progress in patients with complete chronic spinal cord injury. Cell Transplant .2014;23(Suppl 1):S5–S17.
Crossref Google Scholar
11.
Huang H, Chen L. Neurorestorative process, law, and mechanisms. J Neurorestoratol .2015;3:23–30.
Crossref Google Scholar
12.
Huang H. CNS Neurorestoratology. Beijing: Science Press; 2009.
13.
Huang H, Raisman G, Sanberg PR, Sharma H, Chen L. Neurorestoratology. New York, NY: Nova Biomedical; 2015.
14.
Glasser MF, Coalson TS, Robinson EC, et al. A multi-modal parcellation of human cerebral cortex. Nature .2016;536(7615):171–178.
Crossref Google Scholar
15.
Huth AG, de Heer WA, Griffiths TL, Theunissen FE, Gallant JL. Natural speech reveals the semantic maps that tile human cerebral cortex. Nature .2016;532(7600):453–458.
Crossref Google Scholar
16.
Balsters JH, Mantini D, Apps MA, Eickhoff SB, Wenderoth N. Connectivity-based parcellation increases network detection sensitivity in resting state fMRI: An investigation into the cingulate cortex in autism. Neuroimage Clin. 2016;11:494–507.
Crossref Google Scholar
17.
Kamat PK, Kalani A, Rai S, et al. Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of alzheimer’s disease: understanding the therapeutics strategies. Mol Neurobiol. 2016;53(1):648–661.
Crossref Google Scholar
18.
Sekar A, Bialas AR, de Rivera H, et al; Schizophrenia Working Group of the Psychiatric Genomics Consortium. Schizophrenia risk from complex variation of complement component 4. Nature .2016;530(7589):177–183.
Crossref Google Scholar
19.
Hong S, Beja-Glasser VF, Nfonoyim BM, et al. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science .2016;352(6286):712–716.
Crossref Google Scholar
20.
Lui H, Zhang J, Makinson SR, et al. Progranulin deficiency promotes circuit-specific synaptic pruning by microglia via complement activation. Cell .2016;165(4):921–935.
Crossref Google Scholar
21.
Kumar DK, Choi SH, Washicosky KJ, et al. Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease. Sci Transl Med .2016;8(340):340ra72.
Crossref Google Scholar
22.
Hjerpe R, Bett JS, Keuss MJ, et al. UBQLN2 mediates autophagy-independent protein aggregate clearance by the proteasome. Cell .2016;166(4):935–949.
Crossref Google Scholar
23.
Kandul NP, Zhang T, Hay BA, Guo M. Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila. Nat Commun .2016;7:13100.
Crossref Google Scholar
24.
García Santos JM, Inuggi A, Gómez Espuch J, et al. Spinal cord infusion of stem cells in amyotrophic lateral sclerosis: magnetic resonance spectroscopy shows metabolite improvement in the precentral gyrus. Cytotherapy .2016;18(6):785–796.
Crossref Google Scholar
25.
Oh YS, Kim SH, Cho GW. Functional restoration of amyotrophic lateral sclerosis patient-derived mesenchymal stromal cells through inhibition of DNA Methyltransferase. Cell Mol Neurobiol .2016;36(4):613–620.
Crossref Google Scholar
26.
Huang H, Mao G, Chen L, Liu A. Progress and challenges with clinical cell therapy in neurorestoratology. J Neurorestoratol .2015;3:91–95.
Crossref Google Scholar
27.
Kalladka D, Sinden J, Pollock K, et al. Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study. Lancet .2016;388(10046):787–796.
Crossref Google Scholar
28.
Steinberg GK, Kondziolka D, Wechsler LR, et al. Clinical outcomes of transplanted modified bone marrow-derived mesenchymal stem cells in stroke: a phase 1/2a study. Stroke .2016;47(7):1817–1824.
Crossref Google Scholar
29.
Chernykh ER, Shevela EY, Starostina NM, et al. Safety and therapeutic potential of M2 macrophages in stroke treatment. Cell Transplant .2016;25(8):1461–1471.
Crossref Google Scholar
30.
Zhu H, Poon W, Liu Y, et al. Phase III clinical trial assessing safety and efficacy of umbilical cord blood mononuclear cell transplant therapy of chronic complete spinal cord injury. Cell Transplant .2016;25(11):1925–1943.
Crossref Google Scholar
31.
Kakabadze Z, Kipshidze N, Mardaleishvili K, et al. Phase 1 trial of autologous bone marrow stem cell transplantation in patients with spinal cord injury. Stem Cells Int .2016;2016:6768274.
Crossref Google Scholar
32.
Vaquero J, Zurita M, Rico MA, et al; Neurological Cell Therapy Group. An approach to personalized cell therapy in chronic complete paraplegia: the Puerta de Hierro phase I/II clinical trial. Cytotherapy .2016;18(8):1025–1036.
Crossref Google Scholar
33.
Thakkar UG, Vanikar AV, Trivedi HL, et al. Infusion of autologous adipose tissue derived neuronal differentiated mesenchymal stem cells and hematopoietic stem cells in post-traumatic paraplegia offers a viable therapeutic approach. Adv Biomed Res .2016;5:51.
Crossref Google Scholar
34.
Wang S, Lu J, Li YA, et al. Autologous olfactory lamina propria transplantation for chronic spinal cord injury: three-year follow-up outcomes from a prospective double-blinded clinical trial. Cell Transplant .2016;25(1):141–157.
Crossref Google Scholar
35.
Nafissi S, Kazemi H, Tiraihi T, et al. Intraspinal delivery of bone marrow stromal cell-derived neural stem cells in patients with amyotrophic lateral sclerosis: a safety and feasibility study. J Neurol Sci .2016;362:174–181.
Crossref Google Scholar
36.
Petrou P, Gothelf Y, Argov Z, et al. Safety and clinical effects of mesenchymal stem cells secreting neurotrophic factor transplantation in patients with amyotrophic lateral sclerosis: results of phase 1/2 and 2a clinical trials. JAMA Neurol .2016;73(3):337–344.
Crossref Google Scholar
37.
Atkins HL, Bowman M, Allan D, et al. Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. Lancet .2016;388(10044):576–585.
Crossref Google Scholar
38.
Canesi M, Giordano R, Lazzari L, et al. Finding a new therapeutic approach for no-option parkinsonisms: mesenchymal stromal cells for progressive supranuclear palsy. J Transl Med .2016;14(1):127.
Crossref Google Scholar
39.
Cox CS Jr, Hetz RA, Liao GP, et al. Treatment of severe adult traumatic brain injury using bone marrow mononuclear cells. Stem Cells .2017;35(4):1065–1079.
Crossref Google Scholar
40.
Vaquero J, Zurita M, Bonilla C, et al. Progressive increase in brain glucose metabolism after intrathecal administration of autologous mesenchymal stromal cells in patients with diffuse axonal injury. Cytotherapy .2017;19(1):88–94.
Crossref Google Scholar
41.
Xi HT, Chen D. Cell-based neurorestorative therapy for postpoliomyelitis syndrome: a case report. J Neurorestoratology .2016,4:45–50.
Crossref Google Scholar
42.
Ren WQ, Yin F, Zhang JN, et al. Neural stem cell transplantation for the treatment of primary torsion dystonia: a case report. Exp Ther Med .2016;12(2):661–666.
Crossref Google Scholar
43.
Bouton CE, Shaikhouni A, Annetta NV, et al. Restoring cortical control of functional movement in a human with quadriplegia. Nature .2016;533(7602):247–250.
Crossref Google Scholar
44.
Vansteensel MJ, Pels EG, Bleichner MG, et al. Fully implanted brain-computer interface in a locked-in patient with ALS. N Engl J Med. 2016;375(21):2060–2066.
Crossref Google Scholar
45.
Flesher SN, Collinger JL, Foldes ST, et al. Intracortical microstimulation of human somatosensory cortex. Sci Transl Med. 2016;8(361):361ra141.
Crossref Google Scholar
46.
Donati AR, Shokur S, Morya E, et al. Long-term training with a brain-machine interface-based gait protocol induces partial neurological recovery in paraplegic patients. Sci Rep .2016;6:30383.
Crossref Google Scholar
47.
Carlsson CA, Sundin T. Reconstruction of efferent pathways to the urinary bladder in a paraplegic child. Rev Surg .1967;24(1):73–76.
Google Scholar
48.
Tuite GF, Homsy Y, Polsky EG, et al. Urological outcome of the xiao procedure in children with myelomeningocele and lipomyelomeningocele undergoing spinal cord detethering. J Urol .2016;196(6):1735–1740.
Crossref Google Scholar
49.
Yang W, Porras JL, Xu R, et al. Effectiveness of surgical revascularization for stroke prevention in pediatric patients with sickle cell disease and moyamoya syndrome. Neurosurgery .2016;63(Suppl 1):178.
Crossref Google Scholar
50.
Mohamed A, Omi E, Honda K, Suzuki S, Ishikawa K. Outcome of different facial nerve reconstruction techniques. Braz J Otorhinolaryngol .2016;82(6):702–709.
Crossref Google Scholar
51.
Kochhar A, Albathi M, Sharon JD, Ishii LE, Byrne P, Boahene KD. Transposition of the intratemporal facial to hypoglossal nerve for reanimation of the paralyzed face: The VII to XII transposition technique. JAMA Facial Plast Surg .2016;18(5):370–378.
Crossref Google Scholar
52.
Sprigg N, O’Connor R, Woodhouse L, et al. Granulocyte colony stimulating factor and physiotherapy after stroke: results of a feasibility randomised controlled trial: stem cell trial of recovery EnhanceMent after stroke-3 (STEMS-3 ISRCTN16714730). PLoS One .2016;11(9):e0161359.
Crossref Google Scholar
53.
Shin YK, Cho SR. Exploring erythropoietin and G-CSF combination therapy in chronic stroke patients. Int J Mol Sci .2016;17(4):463.
Crossref Google Scholar
54.
Zhao H, Yun W, Zhang Q, et al. Mobilization of circulating endothelial progenitor cells by dl-3-n-Butylphthalide in acute ischemic stroke patients. J Stroke Cerebrovasc Dis .2016;25(4):752–760.
Crossref Google Scholar
Journal of Neurorestoratology
Volume 5 Issue 1,
December 2017
Pages 111-115
DOI: 10.2147/JN.S132589
Cite this article:
Huang H, Mao G, Feng S, et al. 2016 yearbook of neurorestoratology. Journal of Neurorestoratology, 2017, 5(1): 111-115. https://doi.org/10.2147/JN.S132589

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Published: 15 June 2017
© 2017 The Author(s).

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