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Case Report | Open Access

Olfactory ensheathing cell transplantation for a patient with chronic sciatic nerve injury

Feng Zhang1,2, Xiangzhi Meng2, Fang Lu2, Aixian Liu2, Hongyun Huang1,2( )
Cell Therapy Center, Beijing Hongtianji Neuroscience Academy,
Neurorehabilitation Center, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, People’s Republic of China
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Abstract

Objective:

To observe the result of olfactory ensheathing cell (OEC) transplantation in a patient with chronic sciatic nerve injury.

Case report:

A 53-year-old male patient with chronic (1 year) sciatic nerve injury on left side received OEC transplantation at the lesion site. He received follow-up assessment according to the American Spinal Injury Association standard at 10 days, 6 months, and 1 year after OEC therapy. The muscle strength of his left lower limb increased and numbness decreased during the early stage of cell therapy. His motor function improved with each evaluation. His limp walking gait recovered, and numbness sensation got nearly normal after 1 year of follow-up. There were no side effects.

Conclusion:

OEC transplantation may be an option for chronic peripheral (sciatic) nerve injury.

Keywords

olfactory ensheathing cell transplantationsciatic nerve injuryperipheral nerve injuryfunction improvementneurorestoration

References

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Journal of Neurorestoratology
Volume 5 Issue 1,
December 2017
Pages 1-4
DOI: 10.2147/JN.S120524

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Zhang F, Meng X, Lu F, et al. Olfactory ensheathing cell transplantation for a patient with chronic sciatic nerve injury. Journal of Neurorestoratology, 2017, 5(1): 1-4. https://doi.org/10.2147/JN.S120524

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Published: 28 December 2017
© 2017 The Author(s).

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