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Basic Study | Publishing Language: Chinese | Open Access

Effects of basic fibroblast growth factor combined with a collagen membrane on soft tissue defects vascularization in the hard palates of rats

Shuangxi LIU1, Shulan XU2( ), Binping WANG1, Zhuogeng CHEN1
Department of Implantation, Affiliated Haikou Hospital of Central South University Xiangya School, Stomatology Center of Hainan Province, Haikou 570208, China
Implantation Center, Stomatological Hospital of Southern Medical University, Guangzhou 510280, China
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Abstract

Objective

To study the vascularization of the collagen-binding basic fibroblast growth factor (bFGF)-loaded collagen membranes in soft tissue repair in the hard palates of rats.

Methods

Ninety-six male 6-week-old Wistar rats were randomly divided into 4 groups, and 3-mm-diameter circular soft tissue defects were produced from the distal surface of the third molar to the mesial surface of the first molar in their hard palates. The defects were covered with a collagen-targeting bFGF/collagen membrane, a free bFGF/collagen membrane, a collagen membrane or no membrane (control group). Every 6th rat was randomly sacrificed at 1, 2, 4 and 8 weeks in every group after surgery. Wound healing and the number of new blood vessels were measured by hematoxylin-eosin (HE) staining.

Results

The numbers of new blood vessels in the collagen-targeting bFGF/collagen membrane group were 8.94 ± 0.61, 17.39 ± 2.08 and 11.22 ± 1.66 at 1, 2 and 4 weeks after surgery, respectively, which were significantly greater than the values in the other groups (P<0.05). At 8 weeks, the number of new blood vessels in the collagen-targeting bFGF/collagen membrane group was 4.17 ± 1.28, and there was no significant difference in the numbers of new blood vessels between any of the groups (P > 0.05).

Conclusion

Collagen-targeting bFGF/collagen membranes had a favorable effect on promoting angiogenesis during wound healing, and promoted wound healing.

Keywords

Basic fibroblast growth factorCollagen membraneSoft tissue defectVascularizationAngiogenesisTarget
CLC number: R783.4 Document code: A Article ID: 2096-1456(2018)07-0440-05

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Journal of Prevention and Treatment for Stomatological Diseases
Volume 26 Issue 7,
July 2018
Pages 440-444
DOI: 10.12016/j.issn.2096-1456.2018.07.006

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LIU S, XU S, WANG B, et al. Effects of basic fibroblast growth factor combined with a collagen membrane on soft tissue defects vascularization in the hard palates of rats. Journal of Prevention and Treatment for Stomatological Diseases, 2018, 26(7): 440-444. https://doi.org/10.12016/j.issn.2096-1456.2018.07.006

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Received: 18 October 2017
Revised: 09 June 2018
Published: 20 July 2018
© 2018 by Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases

This article is licensed under a Creative Commons Attribution 4.0 International License.