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Basic Study | Publishing Language: Chinese | Open Access

Effects of non-surgical periodontal treatment on level of vaspin and TNF-α in gingival crevicular fluid of type 2 diabetic patients with chronic periodontitis

Lihong WANG1, Wenbiao ZHANG1, Lijun XI1, Aiqin BAO1, Shiguang HUANG2( )
Department of Stomotology, Shenzhen Futian Hospital of Traditional Chinese Medicine, Shenzhen 518034, China
Faculty of Dentistry, School of Medicine, Jinan University, Guangzhou 510632, China
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Abstract

Objective

To investigate the changes of vaspin and TNF-α levels in gingival crevicular fluid (GCF) of type 2 diabetic (T2DM) patients with chronic periodontitis (CP) after non-surgical periodontal treatment.

Methods

60 subjects were divided into 4 groups: DM-CP group (patients with both T2DM and CP, n＝15); CP group (CP patients without T2DM, n＝15); DM group (T2DM patients without CP, n＝15), and CTRL group (systemically and periodontally healthy individuals, n＝15). The clinical parameters of periodontal tissue and GCF were measured before and 8 weeks after non-surgical periodontal treatment. The levels of vaspin and TNF-α were measured by ELISA.

Results

The levels of vaspin and TNF-α in CP group were significantly higher than those in CTRL group (P < 0.05), while the levels of vaspin and TNF-α in CP group were significantly decreased after treatment (P < 0.05). There was a statistically significant positive correlation between the total amount of vaspin and the total amount of TNF-α, the level of HbA1c, gingival index (GI) and probing depth (PD) (P < 0.05).

Conclusion

The results shows that vaspin and TNF- α are greatly decreased in periodontitis after non-surgical periodontal treatment. It suggests that vaspin and TNF- α in GCF may serve as inflammatory markers for the diagnosis and prognosis of diabetes and periodontitis.

Keywords

Visceral adipose tissue-derived serine protease inhibitorTumor necrosis factor-alphaGingival crevicular fluidPeriodontitisType 2 diabetes mellitus
CLC number: R781.4 Document code: A Article ID: 2096-1456(2017)06-0360-06

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Journal of Prevention and Treatment for Stomatological Diseases
Volume 25 Issue 6,
June 2017
Pages 360-364
DOI: 10.12016/j.issn.2096-1456.2017.06.004

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WANG L, ZHANG W, XI L, et al. Effects of non-surgical periodontal treatment on level of vaspin and TNF-α in gingival crevicular fluid of type 2 diabetic patients with chronic periodontitis. Journal of Prevention and Treatment for Stomatological Diseases, 2017, 25(6): 360-364. https://doi.org/10.12016/j.issn.2096-1456.2017.06.004

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Received: 04 January 2017
Revised: 28 March 2017
Published: 20 June 2017
© 2017 by Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases

This article is licensed under a Creative Commons Attribution 4.0 International License.