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Basic Study | Publishing Language: Chinese | Open Access

Effects of 4 kinds of dental metal alloy extraction on expression of inflanmatory cytokine in the inflamed periodontal tissue

Li-xia WU1, Li-li ZHANG2, Yuan-qin WANG2, Lei LI3( ), Shan-shan LIANG4
Department of Periodontics, Huizhou Stomatology Hospital, Huizhou 516000, China
Department of Oral Implantology, Huizhou Stomatology Hospital, Huizhou 516000, China
Department of Oral Implantology, Hospital of Stomatology, Wuhan University, Wuhan 430079, China
Department of Prosthodontics, Hospital of Stomatology, Wuhan University, Wuhan 430079, China
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Abstract

Objective

To evaluate the inflammatory cytokine expressions of inflamed human gingival fibroblast cells (iHGFs) stimulated in 4 types of dental metal extractions.

Methods

Inflamed gingival tissues from 10 patients with periodontitis were collected, and primary iHGFs were cultured. The cells were stimulated by Co-Cr, Ti alloy, pure Ti and AuPd alloy extractions respectively, and DMEM was used as blank control. Protein productions of pro-inflammatory mediators and related mRNA expressions were measured with ELISA and RT - PCR. Statistics were tested with Wilcoxon matched-pairs test.

Results

ELISA and RT-PCR results showed the protein and mRNA expressions of interleukin-6, interleukin-1β, tumor necrosis factor-α in Ni-Cr and Ti alloy groups were both higher than the control group (z = 2.803, P =0.005). However, there was no significant difference in pure Ti and Au-Pd groups compared with the control group (P＞0.05).

Conclusion

Pure Ti and Au-Pd alloy have a better biocompatibility than Co-Cr and Ti alloy in inflamed periodontal tissues.

Keywords

Gingival fibroblast cellCo-Cr alloyTi alloyTiAu-Pd alloy
CLC number: R781.4 Document code: A Article ID: 2096-1456(2016)08-449-03

References

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Journal of Prevention and Treatment for Stomatological Diseases
Volume 24 Issue 8,
August 2016
Pages 449-453
DOI: 10.12016/j.issn.2096-1456.2016.08.003

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WU L-x, ZHANG L-l, WANG Y-q, et al. Effects of 4 kinds of dental metal alloy extraction on expression of inflanmatory cytokine in the inflamed periodontal tissue. Journal of Prevention and Treatment for Stomatological Diseases, 2016, 24(8): 449-453. https://doi.org/10.12016/j.issn.2096-1456.2016.08.003

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Received: 15 February 2016
Revised: 08 May 2016
Published: 20 August 2016
© 2016 by Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases

This article is licensed under a Creative Commons Attribution 4.0 International License.