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Journal of Neurorestoratology 2023, 11(2): 100054 https://doi.org/10.1016/j.jnrt.2023.100054
Review | Open Access | Issue | Published: 26 April 2023

The 2022 yearbook of Neurorestoratology

Show Author's Information Hongyun Huanga( ),  John R. Bachb,  Hari Shanker Sharmac,  Hooshang Saberid,  Sang Ryong Jeone,  Xiaoling Guof,  Ashok Shettyg,  Ziad Hawamdehh,  Alok Sharmai,  Klaus von Wildj,  Dario Siniscalcok,  Paul R. Sanbergl,  Yong Hum,  Mengzhou Xuen,  Lin Cheno,  Fabin Hanp,  Ali Otomq,  Jianzhong Hur,  Qiqing Zhangs
Beijing Hongtianji Neuroscience Academy, Beijing, 100143, China
Department of Physical Medicine and Rehabilitation, Center for Ventilator Management Alternatives, University Hospital of Newark, Newark, NJ, 07102, USA
Intensive Experimental CNS Injury and Repair, Department of Surgical Sciences, University Hospital, Uppsala University, Uppsala, Sweden
Department of Neurosurgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Kyung Hee University, Seoul, South Korea
Department of Neurology, The 981 Hospital of the Chinese People's Liberation Army Joint Logistics Support Force, Chengde, 067000, Hebei, China
Institute for Regenerative Medicine, Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M University, USA
School of Medicine, The University of Jordan, Amman, Jordan
Department of Neurosurgery, LTM Medical College, LTMG Hospital, Mumbai, India
Kvw Neuroscience, WWU Munster, Munster, Germany
Department of Experimental Medicine University of Campania “Luigi Vanvitelli”, Via S. Maria di Costantinopoli 16, 80138, Naples, Italy
Center of Excellence for Aging & Brain Repair, Department of Neurosurgery & Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, 33612, Florida, USA
Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, China
The Department of Cerebrovascular Diseases and, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, Henan, China
Department of Neurosurgery, Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing, 100007, China
The Institute for Stem Cells and Regenerative Medicine, Shandong University/Affiliated Liaocheng Hospital, Liaocheng, 252000, Shandong, China
Royal Specialty Center for Spine & M-Skeletal Disorders, Amman, Jordan
Department of Spine Surgery at Xiangya Hospital of Central South University, Changsha City, China
Institute of Biomedical Engineering, Chinese Academy Medical Sciences & Peking Union Medical College, Beijing, China
Keywords:
Brain-computer interface, Cell therapy, Neurorestoratology, Yearbook, Neurorestorative therapies, Neurostimulation/neuromodulation
Cite this article:
Huang H, Bach JR, Sharma HS, et al. The 2022 yearbook of Neurorestoratology. Journal of Neurorestoratology, 2023, 11(2): 100054. https://doi.org/10.1016/j.jnrt.2023.100054
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Abstract Full text About this article

There was much progress in the field of Neurorestoratology in the year of 2022. It included highlighting advances in understanding the pathogenesis of neurological diseases, neurorestorative mechanisms, and clinical treatments as compiled in the 2022 yearbook of Neurorestoratology. There is still controversy about whether amyloid β-protein and tau protein deposition are the reasons for or the results of Alzheimer's disease (AD) pathology. The fabricated images in important key articles that speculated on the reasons for AD pathogenesis were found. Cholinergic deficiency and decrease or loss in strength of glutamatergic synapse, limited or failing bidirectional cholinergic upregulation in early cognitive impairment, or progressive posterior-to-anterior cortical cholinergic denervation could result in the appearance of AD. Exploration of neurorestorative mechanisms were found in more detail ways in neuromodulation, immunomodulation, neurogenesis, neural network or circuitry reconstruction, neuroprotection, nervous structural repair, and neuroplasticity. Several kinds of cell therapies for neurological diseases showed neurorestorative effects in open-label and/or non-randomized clinical studies or trials. However, mesenchymal stromal cells and mononuclear cells did not demonstrate neurorestorative effects or improve the quality of life for patients with neurodegenerative diseases or neurotrauma including stroke, spinal cord injury (SCI), and amyotrophic lateral sclerosis in randomized, double-blind, placebo-controlled clinical trials (RDPCTs). Clinical treatments through neurostimulation/neuromodulation and the brain-computer/machine interface yielded positive results in AD, Parkinson's disease, stroke, SCI, cerebral palsy, and other diseases in RDPCTs. Neurorestorative surgery, pharmaceutical neurorestorative therapy and other interventions have demonstrated neurorestorative effects for various considered incurable neurological diseases in RDPCTs. Thus, this year, additional guidelines, assessment scales, and standards were set up or revised. These included guidelines of clinical neurorestorative treatments for brain trauma (2022 China version), clinical cell therapy guidelines for neurorestoration (IANR/CANR 2022), SCI or dysfunction quality of life rating scale (SCIDQLRS) (IANR 2022 version). Neurorestorative effects of varying therapeutic strategies with higher standards of evidence-based medicine are now benefiting patients with currently incurable neurological diseases. Hopefully some of them may become routine therapeutic interventions for patients with these diseases in the near future.


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About this article

The 2022 yearbook of Neurorestoratology

Show Author's information Hongyun Huanga( ), John R. Bachb, Hari Shanker Sharmac, Hooshang Saberid, Sang Ryong Jeone, Xiaoling Guof, Ashok Shettyg, Ziad Hawamdehh, Alok Sharmai, Klaus von Wildj, Dario Siniscalcok, Paul R. Sanbergl, Yong Hum, Mengzhou Xuen, Lin Cheno, Fabin Hanp, Ali Otomq, Jianzhong Hur, Qiqing Zhangs
Beijing Hongtianji Neuroscience Academy, Beijing, 100143, China
Department of Physical Medicine and Rehabilitation, Center for Ventilator Management Alternatives, University Hospital of Newark, Newark, NJ, 07102, USA
Intensive Experimental CNS Injury and Repair, Department of Surgical Sciences, University Hospital, Uppsala University, Uppsala, Sweden
Department of Neurosurgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Kyung Hee University, Seoul, South Korea
Department of Neurology, The 981 Hospital of the Chinese People's Liberation Army Joint Logistics Support Force, Chengde, 067000, Hebei, China
Institute for Regenerative Medicine, Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M University, USA
School of Medicine, The University of Jordan, Amman, Jordan
Department of Neurosurgery, LTM Medical College, LTMG Hospital, Mumbai, India
Kvw Neuroscience, WWU Munster, Munster, Germany
Department of Experimental Medicine University of Campania “Luigi Vanvitelli”, Via S. Maria di Costantinopoli 16, 80138, Naples, Italy
Center of Excellence for Aging & Brain Repair, Department of Neurosurgery & Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, 33612, Florida, USA
Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, China
The Department of Cerebrovascular Diseases and, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, Henan, China
Department of Neurosurgery, Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing, 100007, China
The Institute for Stem Cells and Regenerative Medicine, Shandong University/Affiliated Liaocheng Hospital, Liaocheng, 252000, Shandong, China
Royal Specialty Center for Spine & M-Skeletal Disorders, Amman, Jordan
Department of Spine Surgery at Xiangya Hospital of Central South University, Changsha City, China
Institute of Biomedical Engineering, Chinese Academy Medical Sciences & Peking Union Medical College, Beijing, China

Abstract

There was much progress in the field of Neurorestoratology in the year of 2022. It included highlighting advances in understanding the pathogenesis of neurological diseases, neurorestorative mechanisms, and clinical treatments as compiled in the 2022 yearbook of Neurorestoratology. There is still controversy about whether amyloid β-protein and tau protein deposition are the reasons for or the results of Alzheimer's disease (AD) pathology. The fabricated images in important key articles that speculated on the reasons for AD pathogenesis were found. Cholinergic deficiency and decrease or loss in strength of glutamatergic synapse, limited or failing bidirectional cholinergic upregulation in early cognitive impairment, or progressive posterior-to-anterior cortical cholinergic denervation could result in the appearance of AD. Exploration of neurorestorative mechanisms were found in more detail ways in neuromodulation, immunomodulation, neurogenesis, neural network or circuitry reconstruction, neuroprotection, nervous structural repair, and neuroplasticity. Several kinds of cell therapies for neurological diseases showed neurorestorative effects in open-label and/or non-randomized clinical studies or trials. However, mesenchymal stromal cells and mononuclear cells did not demonstrate neurorestorative effects or improve the quality of life for patients with neurodegenerative diseases or neurotrauma including stroke, spinal cord injury (SCI), and amyotrophic lateral sclerosis in randomized, double-blind, placebo-controlled clinical trials (RDPCTs). Clinical treatments through neurostimulation/neuromodulation and the brain-computer/machine interface yielded positive results in AD, Parkinson's disease, stroke, SCI, cerebral palsy, and other diseases in RDPCTs. Neurorestorative surgery, pharmaceutical neurorestorative therapy and other interventions have demonstrated neurorestorative effects for various considered incurable neurological diseases in RDPCTs. Thus, this year, additional guidelines, assessment scales, and standards were set up or revised. These included guidelines of clinical neurorestorative treatments for brain trauma (2022 China version), clinical cell therapy guidelines for neurorestoration (IANR/CANR 2022), SCI or dysfunction quality of life rating scale (SCIDQLRS) (IANR 2022 version). Neurorestorative effects of varying therapeutic strategies with higher standards of evidence-based medicine are now benefiting patients with currently incurable neurological diseases. Hopefully some of them may become routine therapeutic interventions for patients with these diseases in the near future.

Keywords: Brain-computer interface, Cell therapy, Neurorestoratology, Yearbook, Neurorestorative therapies, Neurostimulation/neuromodulation

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Received: 06 March 2023
Accepted: 07 April 2023
Published: 26 April 2023
Issue date: June 2023

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© 2023 The Authors.

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